Skip navigation

Products for Cell Signaling Studies

16 May 2017

AMSBIO has introduced a new range of ready-to-use Reporter Lentivirus for assessing cell signaling activities in virtually any mammalian cell type. 

These pre-made products use a unique combination of transcription factor reporter technology coupled with lentiviral delivery to provide a simple, highly sensitive method capable of operating over a large dynamic range.

By measuring the activities of a reporter, AMSBIO Reporter Lentivirus can be used for performing gene regulation studies in living mammalian cells and for functional genomics as well as drug screening cell signaling assays.  In addition Reporter Lentivirus can be used for generating your own pathway screening assay cell lines for the cell based assay in your desired cell types.

AMSBIO offers a wide range of “signaling pathway lentiviruses” for rapid, sensitive and quantitative monitoring of transduction pathway activation. These lentiviruses express a luminescent or fluorescent reporter under a pathway specific promoter or under a minimal promoter with embedded multiple tandem repeats incorporating pathway specific transcription factor binding motif. The pathway null control lentivirus has the minimal promoter without any signal pathway’s response elements inside the promoter. These lentiviruses also express an antibiotic selection marker or another fluorescent marker under a constitutive RSV promoter which serve as the internal normalization control or as a convenient monitoring method for virus transduction efficiency. Options include androgen and estrogen receptors, JNK, NF-?B , Notch and Wnt signaling pathways.

For further information on Reporter Lentivirus that are safe to use in your laboratory please visit www.amsbio.com/Lentiviral-Vector-Systems.aspx or contact AMSBIO now on +44-1235-828200 / +1-617-945-5033 / info@amsbio.com

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO is able to draw upon in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. Widely acknowledged as an expert in cell culture, AMSBIO partners with clients in tailoring cell systems to enhance organoid and spheroid type screening outcomes from a technological and cost-effective perspective.