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Head of High Throughput Gene Editing

11 May 2018

An exciting opportunity has arisen for a talented scientific manager to lead the High Throughput Gene Editing (HTGE) Core Facility here at the Sanger. The HTGE core facility is part of a cluster of core facilities at the institute, providing DNA sequencing, cell biology and mouse model skills and expertise to the wider institute.

The HTGE team is responsible for the high throughput generation of genetically modified cells and as such supports a wide range of research projects. Currently the team are focussed on the generation of CRISPR mediated gene knockouts in human iPS cells and produce approx. 100 gene knockouts per year.

As the Head of the HTGE core facility you will play a fundamental role in maintaining and developing a highly efficient, groundbreaking service. You will work with other teams across the other core facilities and the wider institute to develop and implement new genetic engineering processes to expand the portfolio of services on offer. As well as challenging the team to explore ways of improving quality and efficiency through new working practises, automation and process streamlining.

You will be providing leadership and direction to a team of approx. 10 scientists, mentoring staff, co-ordinating work and setting standards to ensure the continued high quality and timely delivery of gene editing projects.

Essential Skills:

  • A PhD degree in a biological subject or equivalent scientific experience 
  • Experience in a scientific management role with demonstrable success in delivering a number of projects on time, in budget and to agreed quality standards. 
  • Deep understanding and experience of cell biology and modern genome editing techniques such as CRISPR 
  • Deep understanding and practical experience of modern genome editing techniques, including strategy design, mammalian cell culture, molecular biology, genotyping and next generation sequencing 
  • Experience of successfully line managing teams and resolving a range of people related issues 
  • Highly developed interpersonal skills with experience of taking care of people at all levels successfully 
  • Experience with disseminating information to a wider audience in the form of discussions and seminars as well as the use of online reporting and communication tools 
  • Experience in successfully managing change 
  • Critical thinking skills, and an ability to see the ‘bigger picture’ 
  • Proven organisational skills with the ability to plan and schedule effectively 
  • Strong relationship builder 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments. 

For further information, full job description and to apply please visit 

Interviews likely to take place on 18th June 


Closing date for applications: 3rd June 2018