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Advanced Research Assistant - Cellular Generation and Phenotyping

09 August 2018

An opportunity has arisen for a talented cell or parasite biology specialist to support the Cellular Generation and Phenotyping team (CGaP) here at the Sanger Institute. You will be working as a part of collaboration with the Parasites and Microbes Programme to study gene function of malaria Plasmodium Falciparum and Plasmodium Knowlesi Species using the CRISPR Cas9 technology.

  • Have you ever worked in a R&D, high throughput or process driven setting?
  • Do you have experience working in a CL2 or CL3 laboratory?
  • Are you organised, meticulous and love process improvement?
  • Do you thrive in a multi-disciplinary team, working together to solve complex biological issues?
If you said yes to the above questions, then this is the job for you.

We are a core facility, responsible for providing cell biology resource and expertise to the wider institute. We do this by running multiple, diverse, high throughput projects for various faculty teams from across the Sanger Institute. Our current portfolio of projects includes genome wide CRISPR screens, iPSC derivation and differentiation, organoid derivation, The Human Cell Atlas Initiative and the generation of Plasmodium mutants. We work closely as a team of Senior Scientific Managers, Research Assistants and Faculty members to successfully deliver large scale projects.

As an Advanced Research Assistant you will play a fundamental role in generation, expansion, banking and cloning of Plasmodiummutants using CRISPR technology. Working in partnership with the Malaria faculty team you will develop and transfer protocols into the CGaP facility to enable the project to run at scale. Once the project is established, you will aid in the tracking and progress of mutant parasite lines to ensure a high quality of work and see the project through to completion.

Here at CGaP you will be part of an experienced team of enthusiastic, highly motivated Research Assistants, under the management of a Senior Scientific Manager. Your role will include the culture and manipulation of parasite lines in the lab, co-ordinate the transfer of samples to and from the faculty team, troubleshoot issues, identify areas for process improvement as well as training more junior staff.

In addition to the lab work we expect our Advanced Research Assistants to have strong time management and organisational skills and be excellent communicators. As a department we strive to work together where possible to build a culture of continuous process improvement. We also expect and support all staff to take part in department and institute wide initiatives.

We welcome candidates who are looking for either a full or part-time role, with a minimum of 20 hours per week. Flexibility in working patterns will be discussed at interview.

Essential Skills: 
  • Degree in Biological Sciences, or equivalent qualification
  • Relevant laboratory experience
  • Extensive experience working with primary tissues, cell lines or parasites in a Containment Level 2 Facility
  • Ability to troubleshoot and process improve
  • Experience in collaborating with others and effectively working in teams
  • Good written and oral communication skills
  • Ability to keep good up-to-date records with attention to detail
  • Ability to test and implement new approaches and techniques
  • Ability to work to a schedule and successfully manage and prioritise multiple competing tasks
  • Excellent organisational and communication skills

Ideal Skills:

  • Experience working  at Containment level 3
  • Experience in Plamsodium culture
  • Experience of training others

For further information, full job description and to apply please visit, or click here.

Closing date: 27th August, 2018