BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CiviCRM//NONSGML CiviEvent iCal//EN X-WR-TIMEZONE:Europe/London METHOD:PUBLISH BEGIN:VTIMEZONE TZID:Europe/London BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0100 TZNAME:BST DTSTART:20260917T100000 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT UID:CiviCRM_EventID_2002_e86a4f28f24ec85011f2b11344e0bb4c@onenucleus.com SUMMARY:Webinar - Enabling Membrane Protein CryoEM\, and b eyond\, with Polymer Nanodiscs: A TRPML3 Case Stud y X-ALT-DESC;FMTTYPE=text/html:

Multi-pass membrane proteins\, including GPCRs\, ion channels\, and transporters\, play essential roles in cellular signalling\, communication\, and homeostasis. As the targets of many modern therap eutics\, they remain among the most important yet challenging classes of proteins to study. Difficul ties in expression\, purification\, stability\, an d structural characterisation continue to limit pr ogress across both academic and industrial researc h.

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This webinar is kindly sponsored and presented by...
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In this webinar\, Jim Reid will present a novel polymer nanodisc-based approach that signi ficantly improves the production and performance o f challenging membrane proteins while maintaining a native-like lipid environment. By enhancing puri fication yields\, increasing solubility and stabil ity\, and reducing aggregation\, this platform ena bles researchers to generate high-quality membrane protein samples suitable for a wide range of down stream applications.

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The session will highlight the succes sful application of this technology to TRPML3\, resulting in the first detergent-free cryo-el ectron microscopy (cryoEM) structure of this impor tant ion channel. Beyond structural biology\, atte ndees will explore how the platform can support br oader biochemical\, biophysical\, and functional s tudies\, opening new possibilities for membrane pr otein research and drug discovery.

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< span style="font-family:Aptos\, sans-serif\;">This webinar will also provide an opportunity to discuss emerging applica tions of the technology and engage with researcher s interested in becoming early adopters of this in novative platform.

\n \n < p>Who should attend?

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This webinar is ideal for:

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By attending\, participants will:< /span>

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Join us to discover how next-generation po lymer nanodisc technology is helping researchers o vercome long-standing membrane protein challenges and unlock new opportunities for structural and fu nctional characterisation.

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This webinar is:

\n \n DESCRIPTION:Multi-pass membrane proteins\, including GPCRs\, i on channels\, and transporters\, play essential ro les in cellular signalling\, communication\, and h omeostasis. As the targets of many modern therapeu tics\, they remain among the most important yet ch allenging classes of proteins to study. Difficulti es in expression\, purification\, stability\, and structural characterisation continue to limit prog ress across both academic and industrial research. \n \n \n \n This webinar is kindly sponsored and p resented by...\n \n \n \n \n \n In this webinar\, Jim Reid will present a novel polymer nanodisc-bas ed approach that significantly improves the produc tion and performance of challenging membrane prote ins while maintaining a native-like lipid environm ent. By enhancing purification yields\, increasing solubility and stability\, and reducing aggregati on\, this platform enables researchers to generate high-quality membrane protein samples suitable fo r a wide range of downstream applications.\n \n \n \n The session will highlight the successful appl ication of this technology to TRPML3\, resulting i n the first detergent-free cryo-electron microscop y (cryoEM) structure of this important ion channel . Beyond structural biology\, attendees will explo re how the platform can support broader biochemica l\, biophysical\, and functional studies\, opening new possibilities for membrane protein research a nd drug discovery.\n \n \n \n This webinar will al so provide an opportunity to discuss emerging appl ications of the technology and engage with researc hers interested in becoming early adopters of this innovative platform.\n \n \n \n Who should attend ?\n \n \n \n This webinar is ideal for:\n \n \n \n \n Membrane protein researchers working with GPC Rs\, ion channels\, transporters\, and related tar gets\n Structural biologists using cryoEM\, cryst allography\, or complementary techniques\n Scient ists involved in protein expression\, purification \, and characterisation\n Biophysicists and bioch emists seeking improved membrane protein stability and sample quality\n Drug discovery and therapeu tic development teams targeting membrane proteins\ n Academic and industry researchers exploring det ergent-free methodologies\n \n \n By attending\, p articipants will:\n \n \n \n \n Understand the ch allenges associated with studying multi-pass membr ane proteins\n Learn how polymer nanodiscs provid e a native-like\, detergent-free environment for m embrane protein analysis\n Discover a new approac h for improving membrane protein yield\, stability \, and solubility\n Review the TRPML3 detergent-f ree cryoEM case study and its implications for str uctural biology\n Explore applications extending beyond cryoEM into broader biochemical and biophys ical workflows\n Identify opportunities to apply this technology within their own membrane protein research programmes\n \n \n Join us to discover ho w next-generation polymer nanodisc technology is h elping researchers overcome long-standing membrane protein challenges and unlock new opportunities f or structural and functional characterisation.\n \ n \n \n This webinar is:\n \n \n \n \n Free for O ne Nucleus Gold\, Partner and Corporate Sponsor/Pa tron members\;\n £30 + VAT for One Nucleus Silver Members\;\n £50 + VAT for Non Members.\n CATEGORIES:Events CALSCALE:GREGORIAN DTSTAMP;TZID=Europe/London:20260917T100000 DTSTART;TZID=Europe/London:20260917T100000 DTEND;TZID=Europe/London:20260917T110000 LOCATION:ONLINE - webinar details will be sent to all deleg ates closer to the date of the event\n Cambridge\, \n United Kingdom\n URL:https://onenucleus.com/civicrm/event/info?reset=1&id=2002 END:VEVENT END:VCALENDAR