Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.
We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.
As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.
For all roles, the successful candidate will have good attention to detail and high scientific standards and be able to demonstrate an enthusiasm for their chosen discipline and the broader field of drug discovery. As an organisation, Domainex prides itself on providing innovative solutions to challenging problems, requiring a curiosity and desire to seek-out and apply novel and innovative solutions from the wider literature to progress Domainex’s customer projects and enhance our internal capabilities. All roles will require regular interaction with new and existing customers requiring candidates to have well developed communication and inter-personal skills. Domainex will provide opportunity and support to develop both scientific and personal skills further, as well as exposure to the project management skills and business acumen required to maintain a successful and growing CRO organisation.
Domainex has a permanent vacancy for a PhD level scientist (or BSc/MSc) with relevant industrial experience (preferably in a CRO, pharma or biotech setting) to join our Protein Science Team in a lab-based role. The level of appointment will be commensurate with experience. The Protein Science Team offers our clients a comprehensive range of services including: molecular biology; protein production for biochemical and biophysical assays, and structural biology, including structural analysis of protein-ligand structures by X-ray crystallography.
You will be able to work independently in protein expression (E.coli, insect and/or mammalian), expression optimisation, protein purification optimisation and scale up to multi mg scale for structural analysis, protein QC and protein-ligand crystallisation. You will have demonstratable experience using a range of AKTA chromatography equipment and columns. Experience in crystal manipulation/ freezing, solving protein-ligand X-ray crystal structures independently would be a plus.
The successful candidate will be enthusiastic, a quick learner, good communicator, equally comfortable to work independently and as part of a team, have good problem-solving skills, and be able to work effectively in an inter-disciplinary team and on multiple projects whilst maintaining high quality throughout.
Main Roles and Responsibilities
Plan and implement experimental protein production or structural biology projects, solving any problems that arise
Undertake protein expression (E.coli, insect and/or mammalian), expression optimisation, protein purification optimisation and scale up to multi mg scale for structural analysis, protein QC, protein-ligand crystallisation
Managing client projects
Support routine laboratory operation and maintenance
Prepare and present oral and written reports on research activities to internal and external audiences
Actively pursue own personal development
Maintain appropriate awareness of safety procedures, attend required safety training and adhere to laboratory safety rules as defined by the host department
Ensure that all duties are performed in accordance with organisational standards, policies and procedures
To apply, please sending your CV, quoting reference PSSB1221 to firstname.lastname@example.org. Closing date for applications 31/01/2022