STORM Therapeutics is a University of Cambridge spin-out, translating the ground-breaking work of Professors Tony Kouzarides and Eric Miska in RNA epigenetics into the discovery of first-in-class drugs in oncology and other diseases. It is the leading company tackling cancer through the modulation of RNA modifying enzymes, including RNA methyltransferases, exemplified by the development of a first-in-class METTL3 inhibitor (Yankova et al., Nature 2021). STORM has developed a unique platform to pioneer drug development in this new field of RNA biology and established a pipeline of projects, aiming to take them to the clinic.
We are looking to recruit an enthusiastic Associate Scientist / Scientist to work in our molecular and cell biology team to support our small molecule drug discovery programmes. The successful candidate will be responsible for establishing and running phenotypic assays and testing novel small molecule inhibitors. In addition, they will be involved in target validation studies and RNA pathway analyses for existing and novel drug targets using genetic and pharmacological approaches.
The position is available at the Associate Scientist or Scientist level depending on experience and qualifications.
STORM Therapeutics offers an industry competitive salary and benefits package.
STORM is backed by blue chip investors Cambridge Innovation Capital, Merck Ventures, Pfizer Ventures, Taiho Ventures LLC, IP Group and Seroba Life Sciences who share the founders’ ambitions to build a world-leading company in the field. To date, STORM Therapeutics has raised £42 million of funding. The company occupies modern, well-equipped laboratories on the Babraham Research Campus near Cambridge.
Qualifications and skills required
Essential qualifications and skills include:
• BSc in Biology, Biochemistry or another relevant Biological Science discipline
• Cell biology and molecular biology laboratory experience
• Practical experience working with RNA and DNA
• Knowledge and experience of tissue culture techniques and cellular assays
• Knowledge of cancer biology
• Candidates must be legally entitled to work in the UK.
Desirable additional skills:
• Experience of working with cellular disease models
• Practical application of CRISPR, siRNA or shRNA techniques
• Knowledge of and practical experience with viral transduction systems (adenoviral, lentiviral) and primary cell cultures
• Experience working with complex cell culture models including 3D cell models / organoids
• Experience in Western blotting, flow cytometry, microscopy, qPCR
• Previous work experience in drug discovery or biotech
• Strong oral and written communication skills in English
• Pursuit of the highest standards of scientific excellence
• Excellent organisational skills and a systematic and rigorous approach to work
• High attention to detail
• Result orientated and deadline driven
• Ability to work independently and as part a multidisciplinary team
• A positive and flexible approach to often changing situations.
• Passion for drug discovery
Apply to: email@example.com.