We are now seeking an experienced protein biochemist to join the Biomolecular Structure group at our research facility on Granta Park, Cambridge, UK, working on GPCR structure determination to enable drug discovery efforts.
At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spec, crystallisation and cryoEM facilities. Applicants should be proficient in the expression and purification of membrane proteins destined for biophysical and structural studies. A proven track record of publications related to the expression and purification of difficult membrane protein targets in peer-reviewed journals is desirable.
Knowledge of biophysical (SPR, mass-spec) and/or structure determination techniques (X-ray, cryoEM) of membrane proteins would be a distinct advantage. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.
We are seeking candidates whose profile must include:
A PhD in biochemistry/biophysics/structural biology or a related discipline;
Be proficient in the expression of membrane proteins from baculovirus/insect cells and/or mammalian cells;
Be proficient in the purification of membrane proteins for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spec);
Possess basic molecular biology skills;
Previous experience of working with GPCRs would be advantageous.
The successful candidate is expected to:
Express and purify GPCRs for structural and biophysical studies;
Propose, develop, implement and optimise new techniques in the fields of membrane protein expression and purification;
Perform appropriate quality control analyses on the purified proteins;
Collaborate with other Sosei Heptares scientists on research projects;
Prepare and present results (written and oral) to program teams;
Have strong interpersonal skills and interact effectively with a wide range of staff and collaborators and across a wide range of disciplines.
The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.
We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes.
Applications should include a covering letter, providing a short description of the background to their interest in the role, with a curriculum vitae including the names and contact details for two referees. Please send your application in pdf format, quoting reference number 2019/3BMS.
The closing date for applications is 13th October 2019.
Strictly, no agencies.