Scientist - Biology

A BIT ABOUT US…

At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumor resistance and restore anti-cancer immunity and responsiveness.
We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies.
Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date.
We’re an agile, international team with dual headquarters in Cambridge, UK and Cambridge, Massachusetts. We empower our teams to decide where and when they work to deliver our goals.

YOUR ROLE IN OUR TEAM:
We have an exciting opportunity for a Scientist to join F-star’s Biology Team, as part of the in vivo team, who will be accountable for designing, executing and analysing in vitro, in vivo and ex vivo experiments to further our understanding of the biology and mechanism of action of our bispecific molecules. You’lluse your knowledge and experience of tumour immunology to contribute biology expertise to multi-functional immune-oncology project teams, supporting projects from discovery through to clinical phase. You will need to demonstrate good judgement and effective decision making in applying your expertise in understanding the underlying immunology responses(s) to bispecific antibody intervention.

YOUR KEY RESPONSIBILITIES WILL INCLUDE:
As a valued functional team member and Biology representative on a Project, you will:
• Work with project team(s) to develop programme-specific preclinical strategy that help drive F-star’s pipeline towards clinical development
• Independently design and execute experiments in line with project goals and strategy to achieve project plans and milestones
• Work collaboratively with project and functional teams, as part of a matrix organisation, to deliver on project goals
• Contribute to solving experimental or highly technical difficulties within the department, and bring new ideas to enhance our preclinical and translational capabilities and processes
• Lead, communicate and present strategy and data in the context of scientific literature and competitive intelligence to internal team(s) and externally
• Support the team(s) in building functional technical and scientific expertise

A BIT ABOUT YOU:
This role is flexible enough to suit someone working at a Scientist level, who is looking to advance their career in industry, would thrive on a challenge and embrace a highly collaborative matrix environment.
You’ll be a motivated and enthusiastic continuous learner with an ability to apply learnings to unfamiliar areas. You’ll be organised with strong attention to detail, and a proven ability to work well in teams. You’ll also be committed to sharing and developing alongside others.

YOUR SKILLS, KNOWLEDGE AND EXPERIENCE:
Essentials:
• Significant relevant industrial experience, or a PhD in a biological subject with a focus on immunology, oncology and/or pharmacology.
• Experience working with murine models - syngeneic tumour models would be an advantage.
• Multi-colour flow cytometry to analyse immune cell populations
• Aseptic cell culture technique, and relevant applications (for example, cell-based assays, in vivo model generation etc.)
• Evidence of a track record of successful research, as evidenced by publications (manuscripts, oral presentations, posters, patent, project milestones)
Desirable:
• To have held a Home Office Personal Licence (or international equivalent)
• Experience and/or knowledge of pharmacokinetic and pharmacodynamic analysis relevant to immuno-oncology
• Experience in human in vitro or mouse ex vivo assays (e.g. T cell activity, cytokine release)
• Experience designing and optimising biological and immunological assays for robustness and reliable data quality (e.g. ELISA, MSD, Gyrolab)
• Experience designing and analysing data from experiments to assess gene expression changes (RT-PCR; gene expression array, Nanostring)
• Experience working on drug discovery projects, in academia or industry

WHAT WE CAN OFFER TO YOU:
We get things done, we keep things simple and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference.

Benefits:
• Pension (8% Employer contribution)
• Equity Incentives
• Private Medical Insurance and Health Cash Plan
• Life assurance
• 25 days paid holiday, plus the option to buy 5 days
• Travel insurance
• Enhanced Maternity, Paternity, Adoption pay
• Agile working opportunities

OTHER DETAILS:
This role is to be based from our laboratories and office space based on the Babraham Research Campus, South Cambridgeshire, UK.

This is a full-time time position working 37.5 hours per week. While primarily a laboratory-based role, F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working.

Application Instructions: 

NEXT STEPS…
If you feel this role is right for you, we’d love to hear from you.
To apply, please visit our website: https://www.f-star.com/about/careers/ and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way.
We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications.
If, along the way, you experience any difficulties with applying via our website, please email HR@f-star.com.

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply.
As part of our compliance in relation to the General Data Protection Regulations 2018 (GDPR) you can find our ‘Candidate Privacy Notice’ on the careers section of website.

Application Closing Date: 
8 July 2022