Scientist, GEO

Scientist, GEO

Location: Cambridge, United Kingdom
Type: Full Time
Dept: Tissue Culture, GEO
Education: Mid Level

The Company
We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, CH; and Athens, GA and 82VS portfolio companies in Boston, San Francisco, Dallas and Oklahoma City. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position with flexibility to work from home. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!

The Team
You will be part of the GEO (Genetically Engineered Organisms) Team and work alongside the wider Alloy ecosystem that includes our Discovery Services, 82VS, Bioinformatics and a wide network of partners and collaborators. The goal of our team is to develop innovative transgenic platforms to support the antibody discovery efforts of our internal groups and of our external partners with the ultimate goal of delivering the best medicines to the patients.

We’re a small diverse team and bring together varied experiences and expertise in the fields of mouse genetics, molecular and cellular biology. We work in close collaboration with our partners to develop the next generation of drug discovery transgenic platforms. The GEO team is backed by other functional groups and a robust network of collaborators and consultants, forming a multifunctional unit.

The Role
As a Scientist in the GEO Team, you will be part of a dynamic group involved in the generation and characterization of state-of-the-art transgenic animal models. The position is mainly lab-based, and the ideal candidate will work in our well-equipped research facility located in the Granta park research campus. Your main responsibility will be supporting the work of the Tissue Culture Team in generating high quality engineered mouse ES cells. However, your role won’t be limited to ES manipulation, but it will include additional aspects of transgenic mice generation and characterization. This includes contributing to design targeting strategies and supporting the Molecular Biology Team in characterizing new transgenic strains.

This role requires a candidate who is self-led, possesses excellent communication skills, demonstrates strong troubleshooting and problem-solving abilities, and exhibits adaptability. The candidate will be bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes.

How You’ll Drive Impact
Research & Development: Using your technical skills to overcome challenges, troubleshoot issues and optimize processes to help the team deliver ambitious projects
Quality Control: By applying rigorous and diligent scientific judgment, you will ensure consistency and reliability in your work by evaluating data, methods, and conclusions.
Innovate: By being proactive, curious, and open minded, you will contribute to originating new concepts and ideas and inspire others with your enthusiasm.
Going the extra mile: Take initiative to accomplish tasks without being asked. Being accountable for your work and caring about the success of the team.
Trust: Deliver high-quality work and make sure others know they can trust you to get the job done. Work hard when nobody's watching.
Why We Value You
You possess good knowledge of mouse genetics and innovative techniques in generating transgenic mice
You are familiar with mouse Embryonic Stem (ES) cell manipulation including propagation of ES cells, transfection, colony picking, sub-cloning, quality control, etc
You have a strong grasp of cell culture methods, excellent aseptic technique and are able to troubleshoot problems when they arise.
You are familiar with state-of-the-art molecular biology techniques including CRISPR/Cas9 and homologous recombination genome editing, genotyping techniques, construction of targeting vectors.
You have some experience with characterization of new mouse strains and techniques like ELISA, flow cytometry and Next Generation Sequencing.
You have the ability to adapt to change and can seamlessly integrate into complex workflows whilst juggling multiple projects simultaneously.
You embrace challenges as learning opportunities and stay adaptable.
You are committed to growing your skills and knowledge and have an interest in learning aspects of molecular biology functions that support generation and characterization of transgenic mice.
You possess an innovative mindset coupled with proactive problem-solving skills.
You consistently deliver high-quality work - you care about putting effort into your responsibilities, projects, and tasks.
You hold yourself accountable – you take responsibility for your words, actions, and mistakes.
You maintain a positive attitude that encourages teamwork and collaboration.

Desired Multipliers
Able to work on weekends and bank holidays (on a rota system).
Able to travel to facilities in the Cambridge area to collect/deliver samples or perform short experiments (access to own transportation is advantageous but not essential).
Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Competitive base and equity compensation commensurate with level of experience and independence
Unique Perks
25 annual leave days (with one additional day every 3 years completed.
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Diversity, Equity, and Inclusion
Here at Alloy, we democratize capabilities for discovering and developing therapeutic biologics. So, being diverse and inclusive isn’t just something we strive for, it is who we are, and part of what we do each and every single day. We want to ensure that as an employee, you feel Alloy is a place where, no matter who you are, you feel safe, included, and that you have the opportunity to bring your unique self to work.

Application Instructions: 

Apply for this position via the Careers Page on our website which can be found here:

Application Closing Date: 
31 July 2024