Scientist - Preclinical Translational Pharmacology

POSITION:
Scientist, Preclinical Translational Pharmacology

ABOUT F-STAR:
At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumour resistance and restore anti-cancer immunity and responsiveness.
We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies.
Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date.
F-star’s research team is based in Cambridge UK with an expanding footprint in the US from our Hub in Cambridge, Massachusetts to support our clinical stage requirements.

JOB PURPOSE:
Working within the in vitro pharmacology team as part of the Preclinical Translational Pharmacology (PTP) Department, you will be accountable for designing, executing, and analysing in vitro and ex vivo experiments to further our understanding of the biology and mechanism of action of our clinical molecules. As a Scientist you will use your knowledge and experience of immunology to contribute biology expertise to multi-functional immuno-oncology project teams. You will need to demonstrate good judgement and effective decision making in applying your expertise in understanding the underlying immunological response(s) to bispecific antibody intervention.

KEY RESPONSIBILITIES:
• Independently design, plan and execute experiments in this lab-based role, in line with project goals to support progression of drug candidates through the clinic
• Analyse and present data effectively to line managers, peers, and project teams
• Use expertise to optimise existing in vitro human primary PBMC assays and to develop novel assays to characterise bispecific molecules
• Influence project direction by providing immunological expertise to the pharmacology team and wider clinical project teams
• Contribute to solving experimental challenges or technical difficulties within the department, including training and mentoring of research associates
• Maintain an up-to-date awareness of scientific literature and F-star relevant competitive intelligence
• Maintain up-to-date and accurate records of experiments and data

PERSON SPECIFICATION:
• PhD, or significant experience, in a biological subject with a focus on immunology, oncology and/or pharmacology
• Practical experience in the development and characterisation of primary human in vitro immunological assays, in particular T and/or NK cell biology
• Technically competent in multi-colour flow cytometry
• Experience in running immunoassays e.g. ELISAs, MSD, Gyrolab
• Experience in mouse primary immune cell assays and ex vivo analysis of mouse immune tissue is desirable.
• A fast learner and highly motivated
• Organised with strong attention to detail
• Enthusiasm to learn and optimise new methods
• Strong communication skills and proven ability to work well in teams

What F-star can offer you We get things done, we keep things simple and we are driven by the science. We are ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, teamwork and perks, which make F-star a fun and diverse place to work. And most of all, everyone can make a difference.

Benefits:

• Pension (8% Employer contribution)
• Equity Incentives
• Private Medical Insurance
• Health cash plan
• Life assurance
• 25 days holiday, plus the option to buy 5 days.
• Travel insurance
• Enhanced Maternity, Paternity, Adoption pay
• Flexible working opportunities

Application Instructions: 

To apply for this role, please apply via our website: https://www.f-star.com/about/careers/

Application Closing Date: 
30 April