Scientist, Translational Medicine

Scientist, Translational Medicine
at Bit Bio
Cambridge

bit.bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At bit.bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics.

As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.

Location: Babraham Research Park, Cambridge

Type: Full time, permanent

Start: Immediate

Salary: Competitive

Hours: 40 p/w

Full time Lab Based Position

Your role in our team:

We are looking for a motivated and skilled Scientist, to join our Translational Medicine Team, with a strong background in stem cells, cellular differentiation, cellular reprogramming/forward programming, and functional assays, to support our efforts in developing bit.bio’s research into clinical programmes.

Reporting directly to the Team Lead/Senior Scientist, the candidate will contribute to a team of scientists and research assistants at a focal point between the R&D, Cell Production, and Translational Medicine departments. The main objectives of the team are to functionally characterise bit.bio’s clinical assets, to further develop and enhance cellular therapies through gene editing techniques.

You will work cross-functionally with teams across bit.bio to help develop a product for its eventual use in human clinical trials, as well as contribute to the continuous development of the Translation Medicine team, the laboratory environment and overall aims of bit.bio.

Your key responsibilities will include:

The development and execution of experimental assays to generate specific cell types of interest from human pluripotent stem cells, using cellular reprogramming approaches.
Facilitating technology transfer across teams within bit.bio.
Supporting the design, development, and implementation of the Cell Type Development team. This includes assay design/implementation/execution, LIMS/samples tracking, resource management, SOP writing and process development.
Contributing towards the completion of documentation and reports required during the Cell Type Development process and its milestone stage-gates.
In the collaboration with the leading Senior Scientist, support the cell line and experiment delivery to a wide variety of stake holders.
Supporting junior members of the team by providing intellectual and practical support where needed.
Initiation and execution of experiments, analysis and reporting of results using selected software i.e. Benchling.
Contributing to the development of company strategic programmes by driving innovation in the translational medicine department.
Working in collaboration with other Departments (Research, Cellular Engineering, Manufacturing Development and Production) to meet clinical objectives.

You…

Have a PhD in a relevant area of Biological Sciences, or a MSc in a relevant area of Biological Sciences with a minimum of three years follow up experience in the academic or private sector, and a passion for problem solving.
Have a background and experience in stem cell biology / cellular differentiation / cellular reprogramming / specific cell type expertise.
Are a good team player with an inquisitive mind and an ability to prioritise, organise, and be responsible for your own workload and that of others.
Will be looking for a stimulating working environment where you can engage with different working groups to independently drive research projects and actively contribute to projects of others.
Are process oriented and experienced in implementing workflows, protocols, procedures, and resources.
Are a motivated lab scientist demonstrating the highest scientific rigour, operational skills and work standards.
Are resilient and able to work well under pressure.

With essential experience in…

Strong practical and theoretical background in hESC or hIPSC culture and differentiation/reprogramming (>2 years experience) or functional cell type expertise.
The ability to work collaboratively between teams and specific platforms.
Working and performing in a highly collaborative environment.
Cell phenotyping and functional end point analysis e.g. flow cytometry, qPCR, ICC, MEA analysis.
Self-driven experimental design and prioritisation.
Excellent time management, organisation and communication skills.
Have knowledge of cellular characterisation assays (e.g. immunocytochemistry, flow cytometry, qPCR, multiplexed ELISA systems etc.).

...and possibly....

Well-rounded practical experience and knowledge in the application of cellular therapy in animal models.

More reasons to join us:

bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.

We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.

Creativity and open minds are encouraged for everyone to contribute to the success of the company.

For information on how we will manage your data please see our Candidate Privacy Notice- https://www.bit.bio/candidate-privacy-notice

Application Instructions: 
Application Closing Date: 
16 October 2022