Scientist/Senior Scientist I focusing on identifying and validating DNA damage response targets and agents capable of modulating these targets, for use in combination with radioligand therapies.
The successful candidate will apply their technical expertise in cellular and molecular biology to identify, validate and study targets that sensitize cancer cells to radioligand therapy. This activity will be covered within the collaboration with Novartis.
The experimental activities will include the use of CRISPR/Cas9 technologies, si/shRNA approaches, cell culture, viability assays and immunofluorescence imaging to assess the induction of DNA damage response markers.
The successful candidate will contribute to biological data to the collaborative research between Novartis and Artios and so is an opportunity to work in a multi-disciplinary collaboration with a large pharmaceutical company.
You will join the radiation biology team to identify and validate DNA damage response targets and agents capable of modulating these targets, for use in combination with radioligand therapies. Your primary responsibility will be to perform functional studies to understand how different targets affect tumour sensitivity to radioligand therapy, applying cutting edge technologies such as CRISPR/Cas9 and immunofluorescence imaging. You will have the opportunity to work in a multi-disciplinary collaboration involving a major pharmaceutical company.
Ph.D. in a life science subject or equivalent experience ideally within an industrial setting.
• Proven track record of delivering excellent research
• Ph.D. in a life science subject or equivalent experience ideally within the industrial sector
• Minimum three to five years’ experience working in a research environment
• Experience of in vitro pharmacology or drug discovery
• Experience working in an industrial setting
Essential skills, abilities and aptitudes:
• Excellent skills in a broad range of cell and molecular biology techniques including cell culture, viability assays, Western blotting
• Good understanding of cancer cell biology, in particular as applied to therapeutic approaches
• Willingness to work with radionuclides
• Ability to work independently in an organised and methodical fashion
• High level of team working skills required
• Enthusiasm and commitment to achieve within tight deadlines
• Excellent communication and presentation skills
• Excellent attention to detail and experimental record keeping
• High level of IT literacy
Desirable areas of knowledge:
• Expertise in fluorescence microscopy-based methods such as immunofluorescence and in flow cytometry
• Expertise in CRISPR/Cas9 and sh/siRNA technologies
• Basic understanding of the DNA damage response
• Experience in working with radionuclides
• Demonstrates initiative
• Good communicator and volunteers’ information
• Willing to learn
• Commitment to deliver within tight deadlines
• Approachable and friendly demeanor
• Team player
This is a permanent position, offering an attractive salary & benefits package. If you have the right background, then please apply by sending your CV with a covering letter quoting Ref 4256.
The closing date is Monday 8th August 2022
In order to comply with UK Employment Law, all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.
Due to the high volume of applications we receive; if you do not hear from us we will not be inviting you to interview on this occasion.
No agencies, thank you