Scientist/Senior Scientist, Translational Development

At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumor resistance and restore anti-cancer immunity and responsiveness.
We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies.
Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date.
We’re an agile, international team with dual headquarters in Cambridge, UK and Cambridge, Massachusetts. We empower our teams to decide where and when they work to deliver our goals.

We have an exciting opportunity for a Scientist to join F-star’s Translational Development team to support our early development biomarkers strategy through the exploration, integration, interpretation and reporting of results of multivariate clinical pharmacology data e.g., PK,PD data (such as IHC, immunophenotyping, soluble receptors, receptor occupancy, transcriptomic etc), alongside clinical response data.
You will work as part of multi-disciplinary project teams comprising clinical operational, translational medicine, medical and project management to advance clinical development of F-star drug candidates. When required, you’ll also lead the design, development, and optimisation of in vitro clinical biomarker assays for transfer to external CROs to address the five pillars of clinical/ translational development (right target, right tissue, right safety, right patients, right commercial potential) and establishment of Standard Operating Procedures and protocols. You’ll also be an ambassador for quality in analytical procedures.

• Work with project team(s) to develop programme specific clinical biomarker / clinical pharmacology strategy that help drive F-star’s clinical development decisions.
• Project lead for implementation of clinical biomarker plans and supporting analytical endpoints (e.g., cellular and soluble biomarker assays using flow cytometry and ligand binding platforms such as MSD, Gyros, multi-colour flow cytometry, IHC etc).
• Work with matrix team to develop outsourcing plans for clinical biomarker assay types/platforms/data types and work within the clinical and translational sub teams to analyse and interpret the biomarker in the context of emerging clinical data from our and others’ trials.
• Provide technical oversight and direction for development of assays to meet performance requirements.
• Ensure experiments and data management activities result in robust, quality data to inform decision making on projects.
• Carry out analyses of data to identify issues and implement necessary changes.
• Lead clinical pharmacology data analysis ensuring timely data interpretation and delivery to support project development milestones.
• Support best practice and be aware of regulatory guidelines with a view to transferring methods into a regulated environment to be used under appropriate GxP quality standards e.g., GLP, GcLP, GCP.
• Generate and review presentations for project team meetings, collaborators, and governance teams. When necessary, communicate research results through conference presentations, scientific publications, or project reports (including documents for regulatory submission).
• Work with Bioanalytical and Biomarker outsourcing manager and technical specialists to develop own understanding and provide project and translational context to those individuals.
• Support patent filings where appropriate.
• Read scientific literature and keep up with the new trends and techniques related to role.

This opportunity is flexible enough to suit someone working currently at a Scientist or Senior Scientist level who would thrive on the challenge and embraces a highly collaborative matrix environment.
You’ll be a motivated and enthusiastic continuous learner with an ability to apply learnings to unfamiliar areas. You’ll have team spirit with a commitment to sharing and developing alongside others. You’ll be organised with strong attention to detail and confident in delivering work with limited supervision.
• Prior experience in Immunology and translational research in academic or industry settings, with a PhD in a biological subject with relevant focus on cell biology or immunology or, equivalent industry experience.
• Proven assay development experience and proficiency in a range of assay formats (at least 3 of the following: immunoassays, matrix biomarker assessment, protein analysis by mass spectrometry, multi-colour flow cytometry, Immunohistochemistry, transcriptomics).
• Ability to visualize and interpret data, with a solid understanding of statistics as it applies to bioassays.
• Experience in maintaining quality during multiple ongoing experiments.
• Previous hands-on experience in handling clinical and/or human biological samples.
• Excellent communication and presentation skills with proven ability to work well in cross-functional matrix teams and interact with outside vendors, consultants and collaborators.
• Proficient in designing and optimising biological experiments and/or immunological assays for robustness and reliable data quality, interpretation of data and trouble shooting.
• Extensive experience in record keeping, data recording and understanding of factors affecting assay robustness and levels of data quality.
• Ability to work unsupervised and organised with strong attention to detail.

We get things done, we keep things simple, and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference.

• Pension (8% Employer contribution)
• Equity Incentives
• Private Medical Insurance and Health Cash Plan
• Life assurance
• 25 days paid holiday, plus the option to buy 5 days
• Travel insurance
• Enhanced Maternity, Paternity, Adoption pay
• Agile working opportunities

Our Laboratories and office space are based on the Babraham Research Campus, South Cambridgeshire. This role will require some travel to our offices.

This is a full-time position working 37.5 hours per week. F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working.

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply.
As part of our compliance in relation to the General Data Protection Regulations 2018 (GDPR) you can find our ‘Candidate Privacy Notice’ on the careers section of website.

Application Instructions: 

If you feel this role is right for you, we’d love to hear from you.
To apply, please visit our website: and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way.
We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications.
If, along the way, you experience any difficulties with applying via our website, please email

Application Closing Date: 
23 May 2022