Senior Principal Scientist - Chemical Biology Lead

Job Title: Senior Principal Scientist (Chemical Biology Lead)
Location: Stevenage
Job Type: Permanent, Full Time

At LifeArc, we want to hear from people who are as passionate as we are about making life science life changing that can improve patients’ lives.

A bit about the role:

Working within the new Translational Therapeutic Platforms function, an experienced and dynamic small molecule leader will lead, support and focus the Chemical Biology Team. This role will require both innovation and delivery in the chemical biology space, in support of LifeArc’s Science projects for individual Translational Challenges and/or the wider OneScience portfolio.

Building on LifeArc’s established small molecule capabilities, the new leader will bring additional chemical biology experience as the group refocuses its small molecule strategy.

This is a strategic leadership role that will impact the current and future LifeArc Science project portfolio for Translational Challenges through small molecules approaches, and wider portfolio through creating an innovative culture that allows free-thinking that explores what is and could be possible to maximise our impact for the benefit of patients.

This role is for a dynamic and ‘science focused leader’ to join LifeArc lead a team in a changing organisation that has a unique ability to impact the lives of patients. The candidate will coach and mentor a team, propose improvement and innovation of the platform (both internally and externally) and integrate the team into projects and challenges to provide bespoke chemical biology solutions across LifeArc.

Key accountabilities:

Evolves the Chemical Biology team to refocus small molecule drug discovery in LifeArc
Directs innovative chemical biology (e.g., Protein Degradation, ADCs) to deliver proprietary solutions for future drug discovery
More broadly, applies established medicinal chemistry approaches for small molecule discovery (e.g., fragment and diversity screening)
Oversees matrix working with scientific project teams (and the wider portfolio) in order to provide bespoke small molecule chemistry solutions for projects across the LifeArc portfolio
Provides strategic guidance, knowledge and direction to own team and teams across the organization to support the OneScience approach
Looks for opportunities across LifeArc to where chemical biology can provide bespoke solutions to disease and indication challenges
Uses deep knowledge and experience in chemical biology to scan the external landscape of scientific and technical capabilities with a view to identifying and bringing in house new ‘cutting edge’ capabilities
Drives a culture of innovation across LifeArc, challenging approaches and the status quo, looking for new ways of working and opportunities that will advance our Science and Translational Challenges
Applies proven people leadership and people development skills to coach, mentor and develop the Chemical Biology team of scientists
Identifies and presents project proposals to senior stakeholders, balancing the portfolio in line with Translational needs and impact
Collaborates with the external scientific community, acting as an ambassador for LifeArc promoting, creating and maintaining strategic partnerships
Contributes to project planning and resourcing
Drives a delivery and commercial mindset, where we deliver against our promises and commitments
Critically sets and reviews project outcomes, endorsing or challenging as appropriate to ensure the portfolio is ultimately successful
Shares knowledge of and contributes to current scientific literature and developments within area of expertise
Applies extensive scientific knowledge to significant and critical business issues that address future concepts and services that impact on the success of the organisation

About you:

Education & experience required:

Educated to BSc/MSc/PhD or equivalent
Experience and track record in the chemical biology field, with exemplification in areas such as protein degradation or ADC development
Broad medicinal chemistry skillset with a clear understanding of quality in hits, leads and preclinical candidates
Experience and track record of successful team management
Extensive scientific or post-doctoral experience
Track record of publications or patents that demonstrate the creation of innovative novel solutions to complex problems
Experience managing and resourcing multiple projects
Experience of working in a matrix organisation

Skills & abilities:

Able to thrive in an environment that is ambiguous, which also allows for free-thinking and innovation
Resilient in the face of unfavourable outcomes.
Ability to foster a high-functioning and collaborative team
Ability to coach, mentor and develop individuals in the team and wider organisation
Strong planning and attention to detail
Intellectual curiosity
Highly collaborative with internal and external stakeholders
Critical and analytical thinker, strong problem solver
Organised and meticulous
Detail orientated and accurate
Ability to work well with others
Ability to accurately follow directions
Able to communicate complex information - both verbal and written
Ability to influence and persuade others

About us:

At LifeArc, our ambition is to make life science life changing. We do this by advancing scientific discoveries beyond the lab, faster, so that they can shape the next generation of diagnostics, treatments, and cures. 

Working at the cutting edge of translational science and as the early-stage translation specialists, we progress scientific discoveries on their journey to becoming a medicine, diagnostic or intervention that can improve patients’ lives. Our work begins by seeking out innovative science, then helping to develop this to a point where there is a clinical and commercial pathway for others to invest the time and money to take it further forward. 

What we can offer you:

Salary will be determined by qualifications and experience along with other exceptional benefits. Because we understand everyone has different requirements, our flexible benefits allow you to choose those which are important to you. Our pension scheme offers employer contributions of up to 12%, private health insurance, and annual leave of 31 days PLUS bank holidays. 

Join us, and you’ll have the scope to be creative and take measured risks. You’ll be rewarded for your curiosity, for working as one team, and for learning fast. And you’ll have everything you need to be your best every day. 

Don’t meet every single requirement? Studies have shown that women and people from minority ethnic backgrounds, for example, are less likely to apply to jobs unless they meet every single qualification. At LifeArc we are dedicated in building a diverse, inclusive, and authentic workplace, so whatever your background or lived experience, if you’re excited about this role but your experience doesn’t align perfectly with every qualification in the job description, we encourage you to apply anyway. Our top priority is finding the best candidate and you may be just the right candidate for this or other roles.

We all have potential. At LifeArc, you’ll discover what you can really do with it.

For the right candidate, we will consider relocation and visa sponsorship.



Application Instructions: 
Application Closing Date: 
31 January 2023