SRG: Conjugation Scientist

Bioconjugation - Associate Scientist or Scientist - J34841
A well-established biotech is looking for a protein chemist to join the team working on purification methods for antibody drug conjugate and bioconjugates.
Location: Cambridge
Full Time - 37.5 hours/week
Permanent role
Salary DOE

You will join the team as an Associate Scientist or Scientist to support projects on bioconjugations and develop purification methods for antibody drug conjugate bioconjugates.
You will have a background in protein biochemistry with strong laboratory skills and previous experience of protein chemistry in an industrial setting.

MAIN RESPONSIBILITIES:
• Execute bioconjugation experiments
• Complete conjugation of small molecules and polymers to antibodies and proteins using linker chemistries
• Carry out purification of antibody and protein conjugates by column chromatography using automated systems (AKTA) and membrane ultrafiltration (TFF)
• Characterise antibody and protein conjugates using analytical chromatography techniques, UV-Vis spectrophotometry, microfluidics (CE-SDS, iCEF) and LC-MS
• Perform routine interpretation, reports and presentation of results

SKILLS:
• Bachelor’s or Master’s degree in Chemistry / Protein Biochemistry or related discipline (E)
• 2 years’ experience in an industrial environment, or PhD in a relevant discipline (D)
• Expertise in column chromatography (HIC, SEC, IEX), membrane ultrafiltration, AKTA, microfluidics and LC-MS (E)
• Ability to work to procedures and quality standards (E)
• Working independently and as part of a team (E)
• Knowledge or experience of synthetic organic chemistry (D)
• Serum stability assays and formulation development studies (D)