Platform Scientist

Summary: Scientist I / II
PhoreMost® has developed a next-generation high-throughput screening platform called SITESEEKER® to identify the best new targets for future therapy and the mechanisms to drug them. Our technology is positioned to massively expand the diversity of novel therapeutics across multiple disease areas. We are looking for a talented scientist to join our functional genomic screening team and support our revolutionary discovery campaigns.

Who we are:
We are a biotech located in Cambridge, UK that seeks to open up new ‘druggable’ target space using a cutting-edge approach called Protein Interference®. This technology has the ability to identify hidden, or cryptic, drug sites in disease-relevant proteins, and then target those sites with first-in-class small molecule or biologic therapeutics.

Roles and responsibilities:

Plan and perform pooled functional genomic SITESEEKER screens for internal or external collaboration projects
Assist in the project management of screening programmes to ensure that technical, scientific and reporting milestones are met
Critically review and communicate relevant literature on a screening campaign’s biological rationale to identify model systems and configure screens
Obtain or define new cell models and perform rigorous assay development experiments to establish optimal screening conditions
Design and execute target validation analyses to confirm hits identified from these screens in secondary assays and progress them towards drug discovery

Requirements:

Bachelor’s degree or higher in life sciences with at least three years subsequent research experience
Outstanding technical aptitude in mammalian cell tissue culture
Good team player, enthusiastic, exceptionally driven and actively seeking to learn and develop
Demonstrated capability for successfully and independently balancing the requirements of multiple projects at any given time
Attention to detail, structured thinking, consistent and reliable, excellent communication
Committed to the pursuit of new therapies for critical unmet clinical need

Desired additional qualifications (but not required):

Experience in pooled functional genomic screening (e.g. shRNA, CRISPR, GeneTrap)
Proficiency with lentivirus or retrovirus tools work
Experience with next-generation sequencing data and analysis
A good understanding of statistics and bioinformatics skills (R, Python)

Time: This is a permanent full-time, laboratory-based position.