What are we looking for?
We are looking for a highly skilled and ambitious Scientist to join our Ophthalmology team: with the aim of developing in vitro systems for the generation of novel reprogramming therapies. The right candidate will believe nothing is impossible, and that given the right opportunity, their hard work and adaptability will allow them to achieve the highest standards, delivering world-class science, commercial success, patient impact.
This is a permanent, full-time position at Cambridge Science Park, UK.
At Mogrify, you’ll be joining a passionate and innovative team of world experts whose mission is to pioneer a new class of in vivo reprogramming therapies to treat degenerative disease, using our proprietary suite of platforms to direct cellular reprogramming (Rackham et al., Nature Genetics, 2016) and the maintenance of cell identity (Kamaraj et al., Cell Systems, 2020). Working in a highly dynamic and collaborative environment, you will help to develop revolutionary therapeutic modalities and address disease areas with unmet clinical need, making a difference to your colleagues, collaborators and to the patients we serve.
We believe that success is a journey undertaken by aligned individuals who respect and enjoy each other, an ethos that since its inception has enabled Mogrify to redefine what is possible for an early-stage biotech. To date, we have raised over $40 million USD funding, established a team with unparalleled track records and received recognition from industry peers for our innovation and potential to be transformative in the discovery and development of new medicines.
At Mogrify, you will:
Conduct scientific research for the development of cell and gene therapies using our proprietary direct cellular reprogramming technology, with a focus on in vitro models such as retinal organoids.
Provide scientific expertise for new and ongoing research projects, contributing to all phases of a project, from experimental design through to execution and reporting
Design and conduct experiments to genetically engineer pluripotent stem cells and further in vitro differentiate these cells to generate retinal organoids
Perform functional and phenotypic cell characterization of the generated cells using state-of-the-art techniques.
Work in a highly collaborative environment with other scientists internally and externally bringing a range of disciplines to the project.
Analyze and interpret experimental data from multiple cell conversion experiments, identifying problems or bottlenecks and resolving technical issues.
- PhD in Cellular and Molecular Biology with some relevant experience, or BSc/MSc with demonstrable, relevant follow-on experience
- Experience in the maintenance and differentiation of pluripotent stem cells, and preferably experience in the generation of retinal organoids from pluripotent stem cells
- A background in Ophthalmology or Neuroscience research
- Proficient in cell and molecular biology techniques such as construct design and cloning, gene delivery methods such as cell transfections and/or lentiviral or AAV transductions
- Experience with western blotting, flow cytometry and/or immunohistochemistry analyses is desirable
- Excellent communication (written and verbal) and interpersonal skills
- Team player, organized, self-motivated with positive thinking and a “can-do” attitude
- Ability to work unsupervised, both scientifically and in the laboratory, working on multiple projects
Why Join Mogrify?
You will be joining a pioneering and innovative team who collaborate with shared domain expertise, intellectual curiosity, and passion for developing novel cell reprogramming therapies.
You will have the freedom and flexibility to flourish. We will work with you to create your own personal development plan and provide you with the training, support, and encouragement to continue to enhance your skills.
We look for great, not good, recognizing your efforts with upper quartile remuneration. Colleagues tell us how great our employee benefits package is, and we regularly seek feedback to ensure it remains impactful and meaningful. Our benefits include:
Contributory pension (8%)
Health and dental insurance
Share options scheme
25 days’ annual leave (increasing to a maximum of 30 days)
Recognition scheme (including spot awards and peer recognition)
Fresh fruit, biscuits and other tasty treats are always available in our open plan kitchen and breakout space
Regular and varied, well-attended social events organized by our MOSO committee
How can you apply?
If this sounds like you and you share our core values, and you can also bring something new to our culture, we’d love to share our journey with you. To learn more and apply, please send your CV and a covering letter stating the title of the position you are applying for to email@example.com.