Animal-Free Enzymes for In-Vitro Tissue Dissociation

AMSBIO, in association with Nordmark Biochemicals, is now offering animal-free Collagenase and Neutral Protease enzymes, isolated from Clostridium histolyticum, for in vitro tissue dissociation leading to high yields of viable cells.

Being animal-free, these enzymes are very safe and offer reduced regulatory hurdles for use in clinical applications. They are manufactured under GMP guidelines using a plant-based production process that guarantees no risk of cross-contamination with animal-derived materials. These top-quality enzymes can be used on a wide range of cell/tissue types and are supported with specific protocols available based on each application.

Highly consistent, top quality Collagenase and Neutral Protease are essential tissue dissociation enzymes for tissue engineering and regenerative medicine applications. In addition to the animal-free enzymes, this product portfolio includes a comprehensive range of Collagenase and Neutral Protease enzymes manufactured under GMP guidelines with certified TSE safety and virus validation studies carried out for each batch. The high level of quality control involved in the production of these enzymes means that they have reliable lot-to-lot consistency with accurate analysis of proteolytic enzyme activities.

AMSBIO also offers research grade Collagenase and Neutral Protease enzymes. These research grade enzymes are available with a wide range of enzymatic activities, from standard collagenases, offering balanced amounts of other proteolytic activities, to highly purified collagenases. As each application requires different digestion conditions, this large range of Collagenase NB products offers optimal digestion conditions for a wide variety of tissue types.

To help you find the right enzyme and specific protocol best suited to your choice of cells and tissues, and thereby ensure consistent optimized results, AMSBIO has established an online resource at For further information please contact AMSBIO on +44-1235-828200 / +1-617-945-5033 /  

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading transatlantic company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO has in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. This expertise in cell culture and the ECM allows AMSBIO to partner with clients in tailoring cell systems to enhance organoid and spheroid screening outcomes using a variety of 3D culture systems, including organ-on-a-chip microfluidics. For drug discovery research, AMSBIO offers assays, recombinant proteins and cell lines. Drawing upon a huge and comprehensive biorepository, AMSBIO is widely recognised as a leading provider of high-quality tissue specimens (including custom procurement) from both human and animal tissues. The company provides unique clinical grade products for stem cell and cell therapy applications these include high quality solutions for viral delivery (lentivirus, adenovirus and adeno-associated virus) in addition to GMP cryopreservation technology.

Media Contact Information: 

Dr Bill Bradbury