Presenters will explain how long-term and whole-cell hepatocyte models can be used to improve in-vitro in-vivo correlation predictions and advance drug discovery and development research

BioIVT, a leading provider of biospecimens, research models and services for drug and diagnostic development, today announced that it will host a symposium entitled “Innovative Models for ADME-Tox Research” at Hotel Odelya in Basel, Switzerland on June 22.

“We are delighted to have this opportunity to meet with our biopharmaceutical colleagues in person,” said Jeremy Clarke, Senior Director of Business Development, at BioIVT. “The pandemic proved how resourceful and flexible we can be, as an industry, when necessary to continue the important R&D work that we do. But there really is no good substitute for meeting in person to share research ideas and explore new ways of collaborating.”

Situated in a large private park, the Hotel Odelya is an ideal setting for symposium attendees to share scientific knowledge, network and discuss potential collaborations in a relaxed outdoor setting.

“I am looking forward to hearing how colleagues have used BioIVT hepatic products in novel ways to address unique research problems,” said Scott Heyward, Director of Research and Development at BioIVT. “We believe that BioIVT has the best-in-class platform technologies, but it is always exciting to see customers take our products and models and use them to develop new applications.”

BioIVT’s HEPATOPAC® technology is used extensively in ADME-Tox research because it incorporates metabolic, regulatory, and transporter function to better recapitulate in vivo conditions.

Scott Heyward will open the symposium by describing new applications for the HEPATOPAC long-term liver model. They include a steatosis model for fatty liver disease and the use of small interfering RNA to knockdown the expression of individual genes in HEPATOPAC cultures.

Then, Kenichi Umehara, PhD, Senior Principal Scientist at Roche Pharmaceutical Research, will explain how he used HEPATOPAC cultures to estimate the fraction of a drug metabolized by Cytochrome P450 (CYP) enzymes compared to hepatic metabolism for low clearance compounds.

Julia Riede, PhD, Principal Scientist at Novartis, will describe how she employed primary human hepatocyte spheroids as an in vitro tool for investigating drug compounds with low hepatic clearance.

In the afternoon, Kenneth R. Brouwer, PhD, RPh, Vice President of Technology, ADME-Tox at BioIVT will discuss the regulation of transporter expression and function in polarized hepatocyte models using FXR regulation of bile acid transport as an example.

Then, Melina Malinen, PhD, Senior Scientist at Orion Corporation will outline how she used transporter certified, sandwich-cultured human hepatocytes to investigate the organic solute transporter (OSTα/β) as a bile acid and drug transporter.

Additional information about this complimentary symposium is available at https://info.bioivt.com/basel-event.

About BioIVT
BioIVT is a leading global provider of research models and value-added research services for drug discovery and development. We specialize in control and disease-state biospecimens including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. And as the premier supplier of hepatic products, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and their effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in elevating science. For more information, please visit www.bioivt.com or follow the company on Twitter @BioIVT.