Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to three launched oncology drugs (Kisqali® partnered with Novartis, Balversa® partnered with Janssen and Truqap™ partnered with AstraZeneca). Astex continues to grow and focuses on Neurological Disorders and Oncology.

The Role

We are looking for a talented and self-motivated scientist with strong expertise in protein NMR spectroscopy to join the NMR team within Astex’s Molecular Sciences Group. You will primarily be responsible for providing NMR support for Pyramid™, Astex’s proprietary fragment-based drug discovery (FBDD) platform and will be engaged in FBDD versus a spectrum of oncology and CNS targets. The primary focus will be enabling and prosecuting NMR fragment screening campaigns and developing NMR-based affinity assays. You will be expected to work with and communicate results to NMR technical specialists as well as highly inter-disciplinary project teams.

Astex has recently upgraded its in-house NMR facility, which now comprises 400MHz, 500MHz and 600MHz Bruker magnets equipped with SampleJet automated sample changers and a variety of room temperature and cryogenically cooled probe heads.