Multi-pass membrane proteins, including GPCRs, ion channels, and transporters, play essential roles in cellular signalling, communication, and homeostasis. As the targets of many modern therapeutics, they remain among the most important yet challenging classes of proteins to study. Difficulties in expression, purification, stability, and structural characterisation continue to limit progress across both academic and industrial research.

This webinar is kindly sponsored and presented by...

In this webinar, Jim Reid will present a novel polymer nanodisc-based approach that significantly improves the production and performance of challenging membrane proteins while maintaining a native-like lipid environment. By enhancing purification yields, increasing solubility and stability, and reducing aggregation, this platform enables researchers to generate high-quality membrane protein samples suitable for a wide range of downstream applications.

The session will highlight the successful application of this technology to TRPML3, resulting in the first detergent-free cryo-electron microscopy (cryoEM) structure of this important ion channel. Beyond structural biology, attendees will explore how the platform can support broader biochemical, biophysical, and functional studies, opening new possibilities for membrane protein research and drug discovery.

This webinar will also provide an opportunity to discuss emerging applications of the technology and engage with researchers interested in becoming early adopters of this innovative platform.

Who should attend?

This webinar is ideal for:

• Membrane protein researchers working with GPCRs, ion channels, transporters, and related targets
• Structural biologists using cryoEM, crystallography, or complementary techniques
• Scientists involved in protein expression, purification, and characterisation
• Biophysicists and biochemists seeking improved membrane protein stability and sample quality
• Drug discovery and therapeutic development teams targeting membrane proteins
• Academic and industry researchers exploring detergent-free methodologies

By attending, participants will:

• Understand the challenges associated with studying multi-pass membrane proteins
• Learn how polymer nanodiscs provide a native-like, detergent-free environment for membrane protein analysis
• Discover a new approach for improving membrane protein yield, stability, and solubility
• Review the TRPML3 detergent-free cryoEM case study and its implications for structural biology
• Explore applications extending beyond cryoEM into broader biochemical and biophysical workflows
• Identify opportunities to apply this technology within their own membrane protein research programmes

Join us to discover how next-generation polymer nanodisc technology is helping researchers overcome long-standing membrane protein challenges and unlock new opportunities for structural and functional characterisation.

This webinar is:

• Free for One Nucleus Gold, Partner and Corporate Sponsor/Patron members;
• £30 + VAT for One Nucleus Silver Members;
• £50 + VAT for Non Members.