Amsbio is a premier supplier of high-quality heparan sulfate (HS) monoclonal antibodies for use in brain and neurodegenerative research. In a recent published study** from Stanford University, these antibodies have been used to reveal a key role for endothelial glycocalyx degradation in aging and neurodegenerative disease.

Heparan sulfate is a highly sulphated polysaccharide, synthesized as the glycosaminoglycan component of heparan sulfate proteoglycans (HSPGs). Heparan Sulfate antibodies including clones 10E4, JM403, and 3G10 - serve as critical molecular tools and biomarkers in brain research to map, visualize, and analyse complex glycosaminoglycan patterns.

Glycoproteins play a fundamental role in maintaining the structural integrity and protective transport functions of a healthy blood–brain barrier (BBB). In this area they act as both structural anchors within the brain endothelial glycocalyx and active gatekeepers that control what enters or exits the brain parenchyma.

In the study** the researchers used HS antibodies to help identify brain endothelial glycocalyx dysregulation as a molecular mechanism that contributes to BBB dysfunction in ageing and neurodegenerative diseases. The results from this groundbreaking study demonstrate that restoring the brain endothelial glycocalyx may be an effective therapeutic route to combat BBB breakdown in age-related central nervous system diseases.

Due to its non-immunogenic nature, developing effective antibodies against Heparan Sulfate (HS) has long been a challenge. Amsbio has overcome these limitations by offering a range of hybridoma-derived anti-HS antibodies including 10E4, 3G10, and JM403 that are valuable tools for research. Heparan Sulfate antibodies from Amsbio are widely used by leading brain research groups around the world because of their high sensitivity, specificity, and affinity to target antigens plus they work across many model species. All Heparan Sulfate antibodies supplied by Amsbio are rigorously validated to accurately detect and quantify cell surface Heparan Sulfate, ensuring reliable data for diverse applications from investigating viral infections to exploring cancer and immunological disorders.

For further information on Heparan Sulfate antibodies for brain research please visit https://www.amsbio.com/heparan-sulfate-antibodies/ or contact Amsbio on +44-1235-828200 / +1-617-945-5033 / [email protected]. . To explore additional glycobiology tools supporting glycocalyx and extracellular matrix research visit https://www.amsbio.com/research-areas/glycobiology, To read the Stanford University research study** in full please visit https://www.nature.com/articles/s41586-025-08589-9.

Amsbio, part of the Europa Biosite group, is a leading life sciences company supporting drug discovery, translational research, and cell and gene therapy across Europe, North America, and wider international markets. With in depth expertise in advanced cell culture, 3D cell models, and cryopreservation, Amsbio is well placed to help researchers progress from early discovery through to clinical and GMP-ready applications. The company’s portfolio of innovative products and services supports multiple stages of the research pipeline, spanning target discovery, assay development, and disease modelling, through to stem cell and organoid-based research. Key solutions include the integrated stem cell platform combining StemFit™ media, iMatrix™ recombinant laminins, and CELLBANKER™ cryopreservation technology, alongside extracellular matrix technologies, biospecimens, glycobiology.