The Centre for Protein Degradation (CPD), led by Professor Zoran Rankovic, is a recently established centre at the ICR dedicated to discovering and developing novel cancer treatments through targeted protein degradation. The Centre brings together expertise in medicinal chemistry, structural biology, cell biology and computational science to design PROTACs, molecular glue degraders, and novel E3 ubiquitin ligase chemical probes, with the aim of developing breakthrough treatments for the benefit of cancer patients.

Under the guidance of Dr Andrea Scarpino, we are looking to appoint a Computational Chemist to join the CPD and play a key role in applying and developing innovative computational chemistry methods to accelerate the design and discovery of novel protein degraders. The successful candidate will work in close collaboration with medicinal chemists, structural biologists and biologists within the Centre, contributing computational expertise across all stages of TPD drug discovery - from target evaluation and hit finding through to lead optimisation and candidate selection.