At the forefront of immunotherapy innovation, Creative Biolabs boasts a next-generation custom CAR design and construction platform that allows researchers to create highly specific chimeric antigen receptors for various targets and applications. From streamlining signal domains to selecting best-fit backbones for vectors, their platform is designed for flexibility, precision, and velocity. 

Creative Biolabs leads in hybrid CAR engineering through the design of multi-functional receptor structures that enhance antigen recognition, modulate activation thresholds, and introduce dual-targeting capability. 

"Our hybrid-TCR technology incorporates the constant domains of beta and alpha chains of TCR and the variable heavy (VH) and light (VL) regions of an scFv antibody," stated the department director of CAR-T therapy development. 

Their company specializes in the engineering of logic-gated and tunable CAR constructs to enable researchers to bring engineered immune cells to unprecedented levels in preclinical discovery. 

"Hybrid CAR possesses several distinctive features that make it superior to conventional CAR designs, particularly for solid tumor targets," said a scientist at this company. 

Along with this, CAR-T therapy in dogs has also demonstrated early potential against solid tumors. Research indicates that B7-H3 is a promising target, and some dual CAR constructions—like B7-H3 with CXCR2—are effective for tumors in animal models. 

Creative Biolabs provides a one-stop CAR-T development service for solid tumors. They also offer a series of popular research targets of solid tumors. Below are several highly effective targets for customers to choose from, including but not limited to B7-H3, HER2, CLDN18, GPC3, CA9, and FAP. With Smarter™ CAR constructs as the cutting-edge platforms, they are able to address the special challenges of solid tumors. 

From design concept to in vitro validation, Creative Biolabs offers complete support, accelerating discovery while maintaining rigorous quality at every step. Backed by a dedicated team of scientists and engineers, they not only offer reagents but also strategic advice and technical partnership as well. 

Where innovation demands adaptability in today's world, Creative Biolabs is a force behind personalized CAR-T development—ready to equip researchers with the tools to redefine the possible.