Laboratory Solutions are working with a rapidly expanding Antibody engineering company who have a Global reach. They are looking to hire an experienced Antibody discovery scientist, if this could be your cup of tea, have a read of the spec below!
 

Main Duties/Responsibilites:

• Expected to independently carry out phage display campaigns, from naïve selections to affinity maturation.
• Willingness to take the lead on programme teams as the “antibody expert”, to advise on antibody engineering aspects and to effectively select leads that will lead to drug candidates.
• Aid in the building of new libraries, both practically and theoretically.  Able to build affinity maturation libraries for key candidates.
• Expected to express and purify lead antibodies to small scale, and to conduct initial binding and biophysical screens.  Able to work closely as part of a matrix team to make decisions on the best antibody candidates to take forward.
• Expected to give regular presentations.
• Manage all antibody data within the project and collate results.
• Laboratory based – is willing to take the lead within the laboratory and serve as subject matter expert.
• Is willing to supervise and mentor 1-2 scientific staff within the phage display group.
• Maintain a current and accurate laboratory record (lab notebook) of all activities.
   

Qualifications and Experience:

• MSc with >7 years industrial experience or PhD in a biological science/biochemistry discipline. Experience in an industrial setting is desirable.
• Experience in phage display, particularly with ScFv and/or Fab formats. Able to work independently in panning and selections of antibody formats for a variety of targets.
• Able to identify and characterise lead clones from phage display campaigns using a variety of assays (RBA, ELISA, Biacore etc) to progress drug discovery programmes.
• Excellent molecular biology skills: cloning, PCR, sequence analysis.
• Protein expression and purification on small scale skills are required. Experience in HTS expression and screening of antibodies would be advantageous.
• Experience with BIAcore and/or Luminex as tools to screen antibodies would be desirable.
• Experience with affinity maturation of antibody fragments using a variety of techniques.
• Experience in yeast display or other display technologies would be an advantage.
• Excellent written and verbal communication skills. Can work effectively as part of a multidisciplinary team.
• Ability to present data locally, company-wide and to external collaborators.
• Strong analytical and critical thinking skills with the ability to interpret complex data.