Director DMPK

Director DMPK

OMass Therapeutics is an early-stage drug discovery company, applying its unique OdyssION™ technology platform, which comprises novel biochemistry techniques, next-generation native mass spectrometry, and custom chemistry, to discover small molecule therapeutics for rare diseases and immunological conditions.

The company was founded by Professor Dame Carol Robinson to leverage her pioneering work in native mass spectrometry, in studies of dynamic protein assemblies, to characterise challenging drug targets including membrane proteins. With state-of-the-art laboratories OMass is able to perform high resolution native mass spectrometry, pharmacological studies, chemical computational analysis and more recently structure determination, including crystallography and cryo-EM. The high resolution of our biophysical platform offers an unprecedented advantage in the detection of drug leads. The company vision is to build an integrated drug discovery company, with the ambition to develop and ultimately commercialise our products.

Headquartered in Oxford, UK, OMass has raised over $150M (£119M) from a top-tier international investor syndicate, including Syncona, Oxford Science Enterprises, GV, Northpond Ventures, and Sanofi Ventures. This is an excellent time to join our dynamic growing company.

OMass Therapeutics is recruiting a Director DMPK to report to the VP Medicinal Chemistry. As a key member of the OMass R&D leadership team, the Director DMPK will work closely with Medicinal Chemistry, Bioscience, Pharmacology and senior leadership as well as our proprietary MS platform technology leaders to provide DMPK leadership in the design, implementation and analysis of nonclinical DMPK studies. In this role the Director DMPK will direct the activities of CROs to conduct in vitro and in vivo DMPK/ADME studies, supporting multiple projects across different therapeutic areas, from lead identification and optimisation phases through to candidate selection. The Director DMPK will contribute to the preparation of nonclinical DMPK reports and relevant components of regulatory submissions to help drive project advancement into clinical development. The principal place of work is flexible, however, candidate should have flexibility to travel as required by the business. This is expected to include regular on-site time in Oxford. The company offers a collaborative and innovative environment for a well-suited candidate to become an integral part of our future vision.

This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge in drug discovery technology to develop disease modifying medicines for patients.

The successful candidate will possess a PhD (or equivalent) in a scientific discipline with significant and demonstrable experience in the pharmaceutical and/or biotechnology industry including comprehensive understanding of DMPK science with additional knowledge of related disciplines and extensive experience of DMPK from pre-clinical to first in human.

Applications to be received by 12th September 2022

Essential Experience, Skills and Qualities
• Degree or PhD in Biology, Pharmacy, Pharmacokinetics or related pharmaceutical science
• Extensive pharmaceutical industry, biotech and/or CRO experience with a track record of contributing DMPK expertise from pre-clinical to first in human
• In depth understanding of applying state-of-the-art DMPK concepts in the successful discovery of drug candidates through effective compound optimization, translational PK-PD, PB-PK modelling and human dose optimization strategies
• Thorough knowledge of FDA, EMA, MHRA, and ICH guidance documentation
• Experience in utilising, managing and strategic use of external contract research organisations
• Responsible and focused approach to independent and collaborative work, with the ability to prioritise and deliver high quality work to deadlines
• Innovative and ambitious mindset, with an inquisitive and agile approach to problem-solving and overcoming technical challenges; motivated to continuously learn and take on challenges in the pursuit of delivering novel therapeutics
• Caring and inclusive; respectful and receptive to others’ diverse ideas, experience and perspectives, and enjoys working collaboratively with others as a team
• Excellent communication skills, both written and verbal, with a high attention to detail

Preferred Experience and Skills
• Ability to navigate and work effectively in a fast-paced, matrix-team work environment
• Broad experience of the management, mentoring and scientific direction of scientists
• Experience in PK, PB-PK and PK-PD modelling to support for pre-clinical and clinical projects
• Authorship of regulatory documents including INDs, CTAs and NDA filings
• A hands-on approach to personally leading project and R&D success
• Strong organisational skills with an ability to prioritise work accordingly to project goals and take responsibility for the timely delivery of objectives
• A strong sense of urgency and focus to deliver successful outcomes

Role Responsibilities
• Proactively implement DMPK strategy across discovery and development
• Represent DMPK on multidisciplinary projects and provide scientific leadership and strategic direction to all OMass research programs
• Work collaboratively with Medicinal Chemistry, Pharmacology and Bioscience colleagues in the design and identification of candidate molecules to help advance different projects
• Design, commission and conduct appropriate experimental studies to support compound optimisation, project progression and candidate selection to understand and resolve project ADME challenges
• Identify and effectively manage external CROs partnerships
• Identify DMPK recruitment needs and lead on recruitment, capital budget and implementation
• Provide scientific and managerial leadership to DMPK team
• Develop and write protocols, study reports and regulatory INDs, CTAs and NDA documents
• Be a positive role model and value the importance of maintaining a positive workplace culture
• Bring a fresh perspective into the team and the enthusiasm to tackle new challenges and learn new skills
• Share information openly and work collaboratively with other departments to help advance different projects and achieve company goals
• Promote and adhere to OMass’ values of being Ambitious, Responsible, Innovative, Focused, Caring and Collaborative
Applicants should provide a full CV and a brief cover letter describing their interest for, and compatibility with, the position.

All applications should be submitted online via our website www.omass.com/working-here/
Any queries relating to the role can be sent to jobs@omass.com.
Job Type: Full-time, Permanent
Location: Oxford
Salary: Competitive salary and comprehensive employee benefits

OMass Therapeutics values diversity and is committed to equality of opportunity, we also have full responsibility to ensure that all employees are eligible to work and live in the UK.