Drug Discovery Scientist

Start Date: Immediate preferred

Salary: Competitive compensation package including share options, subject to experience

Closing Date: 20th December 2019

About Healx

Healx is a fast growing Cambridge, UK startup combining computational methods and drug discovery expertise to identify existing drugs that may treat rare diseases, enabling treatments to be found at a fraction of the time and cost of traditional drug discovery. There are over 7,000 rare diseases that affect an estimated 350 million people worldwide, most of which lack effective treatment. Working closely with patient groups and charities to understand clinical unmet need we have a growing portfolio of treatments derived from our AI platform which are now moving into clinical evaluation.

We're now looking to expand our team by incorporating further breadth in key drug discovery disciplines.  As a talented drug discovery scientist, you will lead the identification and clinical translation of drug repurposing candidates in the rare disease space. Through the use of your experience in medicinal chemistry, DMPK and pharmacology you will evaluate predictions made by the AI platform and select potential treatments for clinical translation. 

The role 

- Lead the translation of drug candidates to preclinical /clinical stages, providing in vitro / in vivo study design input
- Analyse and filter results from Healx' predictive methods and establish a pharmacological rationale for potential
drug repurposing candidates
- Evaluate the appropriateness of drug properties (e.g. DMPK) of repurposing candidates
- Work with bioinformaticians and software engineers developing algorithmic methods and tools, provide drug
discovery expert input for new developments
- Compile reports including chemical, biochemical, pharmacological, pharmaceutical, pharmacokinetic etc. for
regulatory packages for candidate drugs
- Interact with charities and partners on drug discovery matters
- Work with CEO, CSO and Head of Business Development to generate and maintain long term relationships with Healx partners

Who we're looking for 

- University Degree (with at least a 2:1) and postgraduate degree from a top university in Medicinal Chemistry,
DMPK, Pharmacology or related discipline.  
- A detailed understanding of disease pathways and drug pharmacology gained through a minimum of 5 years of experience in a pharmaceutical environment or similar is essential
- In depth-knowledge of drug discovery and drug development process
- Experience in contracting/directing CROs and AROs
- Experience of pre-clinical study design
- Experience in drug repurposing and project leadership is desirable

How to apply

Please submit your CV and cover letter to apply.  Applying by any other means may not be successful. 

For more information about Healx and how we use your data please go to https://healx.io/privacy/

Please note - We are not currently using Agencies 

 

 

Application Instructions: 

Please apply via our website https://healx.io/careers/?gh_jid=4520166002

Application Closing Date: 
20 December