Company Description
Sosei Heptares is an international biopharmaceutical group focused on the design and development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of partnered and in-house drug candidates in multiple therapeutic areas including neurology, immunology, immuno-oncology, gastroenterology and rare/specialty diseases. Sosei Heptares is a world-leader in engineering of functional, stabilized GPCRs in their natural pharmacological conformations (agonist or antagonist), enabling the determination of 3D structures of GPCR-ligand complexes useful for SBDD.
Sosei Heptares has approximately 145 employees based in the new R&D research facility at Granta Park.
The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.
Position
We are seeking a highly motivated and skilled Principal Scientist with experience in Computer-Aided Drug Design (CADD) to join the Computational Chemistry team to assist Sosei Heptares in its drug discovery programs. Sosei Heptares is now based in new R&D facilities in Cambridge, UK. This is an exceptional opportunity to participate in cutting-edge science using unique structural data whilst helping the growth and success of an industry-leading drug discovery company.
Requirements
Our preferred candidate will have the following profile:
• Ph.D. in computational chemistry, cheminformatics or a related discipline.
• Extensive, relevant post-PhD experience, with a strong track record of scientific achievements in a collaborative, multi-disciplinary pharmaceutical or biotech environment.
• A credible publication track record, consistent with length of experience
• Established expertise in computational chemistry/CADD approaches and proficiency in the use of computational chemistry software suites for structure-based drug design
• Significant experience in Shell/Python scripting and the development and application of cheminformatics tools/workflows
• Hands on experience of working collaboratively with medicinal chemists in SBDD projects, and other project teams, incorporating knowledge of small molecule properties based on a good understanding of medicinal chemistry
• Experience in G Protein-Coupled Receptor drug discovery is preferred
• Advanced analytical and critical problem-solving skills, combined with scientific creativity and a proactive, positive can-do attitude
• An effective team player, with two-way communication skills, but at the same time highly self-motivated and able to work independently with excellent time management
• Fluency in written and oral English, and strong, written, oral communication and influencing skills.
All applications should be made via our Sosei Heptares website: https://soseiheptares.com/global-jobs-portal. You should include a covering letter, providing a short description of the background to your interest in the role, with curriculum vitae including the names and contact details for two referees.
Applicants must be able to demonstrate proof of the right to work in the United Kingdom.
We offer a competitive salary and benefits package commensurate with qualifications and experience.
Sosei Heptares is an equal opportunities employer.
Strictly no agencies.