Location: South Cambridge
Contract type: Permanent

About the Company

T-Therapeutics is a venture-backed company on a mission to unlock the power of T cells to treat chronic and infectious diseases.
Based on technology from Professor Allan Bradley’s laboratory in Cambridge University’s Department of Medicine, T-Therapeutics has secured significant investment from a blue-chip syndicate of investors to support its drug discovery efforts and prepare candidates for clinical development.
T-Therapeutics was founded in 2022, and we are at the very beginning of our journey to develop transformative T cell derived medicines. To realise our ambition, we are currently building facilities, recruiting staff, and establishing our research operations.

(Senior) Research Associate – Pipeline – Expression

About the Opportunity

We are seeking a Research Associate to join our Pipeline Expression team. The team is developing an expression platform to generate high quality molecules for TCR-based therapies. The role is primarily lab-based, and includes both verbal and written communication, along with the requirement for good organisation. This an excellent opportunity to contribute to the development of advanced medicines that can impact the lives of patients around the world.

In this role you will be responsible for:

Small and medium scale expression of molecules in relevant cell lines (including mammalian and bacterial)
Carrying out routine and optimisation work to enhance the protein expression
Molecular biology and related tasks to generate vectors required for expression
Use of automated liquid handling systems to carry out high-throughput protein expression, purification and assay set up
High-throughput affinity measurements of TCRs
Work with project teams to provide data and progress updates for relevant molecules
Trouble shooting and technology development when required
Precise recording of daily laboratory work
Verbal and written communication to colleagues

About You

MSc or equivalent practical work experience (3yrs) in a relevant field of cell culture or protein expression
Experience of mammalian cell culture for protein expression (2yrs)
Ability to perform a wide range of molecular biology techniques such as PCR, sequence analysis, various cloning techniques (1yr)
Excellent communication skills for reporting (written & presentation) and experimental lab book write-ups
Quick to learn the use of lab instrumentation and new experimental techniques
Experience of effective team and matrix working in a dynamic environment.
Ability to multi-task and work across multiple projects simultaneously

Experience in some of the areas listed below would be advantageous:

Methods to measure binding affinities such as Biacore and other SPR techniques for characterization of TCRs.
Use of Hamilton (or similar) automated liquid handler platforms
Protein purification and quantification techniques
Flow cytometry techniques
Generating NGS libraries

Company Benefits

T-Therapeutics offers employees a wide range of benefits. These include a generous pension contribution, life insurance, health insurance and a health cash plan. Employees will be offered share options in the company, as well as 28 days’ holiday each year (not including standard bank holidays).
You will have the opportunity to contribute to innovative drug development, in an open environment, able to learn all aspects of drug development. T-Therapeutics is also committed to enabling staff to grow professionally in a variety of ways as well as providing the chance to develop cutting-edge technologies.