PolyProx Therapeutics is a spin-out from Cambridge University, Department of Pharmacology based on exciting discoveries in the PROTACs/proteasome field. The company is looking to develop a new class of drugs for the treatment of cancer, using novel engineered proteins that are able to selectively target tumour cells and trigger natural degradation machinery within the cell. We call these proteins 'Polyproxins®'.
PolyProx has raised seed financing of £4.4m to build and validate a drug discovery pipeline for several cancer drug targets. Based in R&D laboratories on the Babraham Research Campus we are currently recruiting a team of scientists.
Responsibilities include (but not limited to):
* Develop and perform assays to characterise intracellular target protein degradation
* Develop assays and screen polyproxins for expression and specific degradation of target proteins
* Develop functional assay to demonstrate MOA of polyproxins
* Evaluate different polyproxin delivery methods in vitro
* Complying with current health and safety codes of practice and quality initiatives
* Setting up and managing projects with CROs (for more senior hires)
Experience:
* Cell biology
* Laboratory skills in cell biology, transfection, luminescent and immunofluorescence assay development.
* Assays development and running cell bioassays (reporter gene, IF and bioluminescent readout, ELISA)
* Screening candidate drug molecules for activity
* Experience working with the InCell
* Quantification of proteins by Western Blot
* Experience delivering protein/RNA in-vitro and/or in-vivo
* Experience within industry
BENEFITS
We offer competitive salaries and an attractive benefits package that includes 6% pension contribution, life assurance and healthcare plan.
For further information and how to apply, please visit our website:
www.polyprox.com/careers
Applicants must have the permanent right to work in the UK