bit.bio

Cambridge, UK

bit.bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At bit.bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics.

As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.

Location: Babraham Research Park, Cambridge

Type: Full time, permanent /

Start: Immediate

Salary: Competitive / Hours: 40 p/w

Lab based position

Your role in our team:

We are looking for a Scientist with experience in Cellular Engineering, tissue culture, and molecular biology, to plan, perform and evaluate genome engineering experiments in Human iPSCs and mammalian cells.

Reporting to the Cell Engineering Lead, and with input from the Director of Functional Genomics, this position has 2 major focusses; supporting the requirements of the Cellular Engineering platform to provide high quality cell line deliverables, and assisting in the management, training and development of Cell Engineering staff. Working closely with the Technological Development team, you will also support the development and implementation of novel gene editing techniques as pertains to the team and company wide Objectives and Key Results (OKRs).

Your key responsibilities will include:

Support the design, development and implementation of a state-of-the-art Cellular Engineering platform. This includes assay design, implementation, execution, LIMS/sample tracking, resource management, SOP and process development
In concert with the Functional Genomics Technology Development team, incorporate novel Cellular Engineering and gene editing technologies, processes and applications into the Cell Engineering platform
Responsibility for cell line and reagent delivery to a wide variety of stake holders; internal scientific, manufacturing and external academic and contract research organisations
Line management responsibility of 1-2 direct reports.
Engage and influence wider bit.bio scientific and manufacturing community, external collaborators (and suppliers). Be involved in initiating, developing and driving collaborations which are critical to the achievement of the team and company Objectives and Key Results (OKRs).
Will sit on a number of key committees.
Oversee development and training activities; coach individuals to perform their roles effectively. Help to manage the performance of individuals who are failing to meet agreed standards.
Contribute to and troubleshoot 'the big picture' ideas.
Actively lead in developing and maintaining the core cultural aspects of the company.
You…

Are a good team player with an inquisitive mind and an ability to prioritise, organise and be responsible for your own workload and that of others.
You will be looking for a stimulating working environment where you can engage with different working groups to independently drive research projects and actively contribute to projects of others.
You have a passion for Cell Engineering and problem solving
With essential experience in...

A PhD in a relevant area of Biological Sciences or equivalent experience
Strong practical and theoretical background in hESC or iPSC culture
Strong practical and theoretical background in genome editing of human iPSCs and mammalian cell, experiment QC and project delivery
Demonstrable experience and/or understanding of genotyping strategies and interpretation of genotyping results.
Practical experience and/or a demonstrable understanding of molecular processes including DNA extraction, PCR, ddPCR, Q-PCR and DNA sequencing.
Track record of optimising protocols including the experimental design and empirical assessment of alterations to, or troubleshooting established SOPs.
Ability to use sequence manipulation software (such as Seq Builder, Snapgene, Benchling).
Ability to manage and prioritise own workload.
Ability to effectively communicate with collaborators and present oral communications to large groups.
and possibly...

Experience of using Electronic Laboratory Notebooks
Experience in the use and incorporation of automated workflows
Experience in working with IT and informatics teams to develop sample and experiment tracking software/systems
Well-rounded practical experience and knowledge of cellular assays and cell phenotyping (FACS, IHC, clonogenic, cytotoxicity and viability)
Good knowledge and experience of performing modern genomic screening technologies
Experience of generating library preps for NGS
Experience and understanding of introducing novel workflows/processes and development of platforms for reagent delivery
Line management experience
Ability to engage and motivate others
Experience of coaching, training and development
More reasons to join us:

bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.

We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.

Creativity and open minds are encouraged for everyone to contribute to the success of the company.

For information on how we will manage your data please see our Candidate Privacy Notice

https://www.bit.bio/candidate-privacy-notice