Scientist / Senior Scientist - CRISPR

Scientist / Senior Scientist - CRISPR

Location: Cambridge UK - Joint AstraZeneca CRUK Functional Genomics Centre

Contract: Permanent and full time

Salary: Competitive + benefits

Closing date: May 20th, however please note that we will be reviewing applications as they come in so early application is strongly advised to avoid disappointment.

Cancer Research UK and AstraZeneca have recently announced the opening of a new state of the art facility in the UK, dedicated to realising the full potential of functional genomics to accelerate the discovery of new cancer therapeutics. The Joint AZ-CRUK Functional Genomics Centre (FGC) will be a centre of excellence for CRISPR screening technology, cancer models and computational approaches to big data on the Cambridge Biomedical Campus.

As part of this initiative, Cancer Research UK – Therapeutic Discovery Laboratories (CRUK-TDL) is now recruiting for several laboratory-based positions at Associate Scientist, Scientist, and Senior Scientist levels (grade dependent upon experience) within the CRISPR screening team. These roles offer the unique opportunity to be part of an exciting team, operating at the forefront of research and technology development, gaining experience across the breadth of CRISPR screening whilst it is being applied to clinically actionable programs. These roles require strong team players with excellent communication and organisational skills who are able to work independently and collaboratively to deliver on specific project goals and deadlines.

Key Duties and Responsibilities (Dependent upon grade)

Responsible for the delivery of pooled CRISPR screening
To work independently to design, develop and implement experimental plans, including: Generation of Cas9 expressing cell lines, production of pooled lentivirus libraries, optimisation of screening conditions, execution of pooled CRISPR screens, preparation of samples for NGS
To implement experimental plans over agreed timelines such that the objectives of the projects are met; Senior roles will be expected to lead aspects of scientific disciplines within the team
To maintain an awareness of current technological developments and apply these to improve experimental design and assay performance
Senior roles may include; providing mentorship, training of staff and possible line management
To view a full job description please click here.

Technical Skills and Attributes

Experience in molecular and cellular biology techniques essential
Practical experience in the field of CRISPR screening for use in target discovery is beneficial
Experience in assay development would be desirable
Demonstrable commitment, enthusiasm and a passion for self-improvement and learning
Strong interpersonal skills with the ability to quickly build relationships and work well in a team
Experience in an industrial/pharmaceutical laboratory applying relevant molecular and cell biology techniques would be advantageous
At CRUK we value diversity and we're committed to creating an inclusive culture where everyone is able to be themselves and to reach their full potential. We actively encourage applications from people of all backgrounds and cultures and believe that a diverse workforce will help us to beat cancer sooner.

Please note, from October 2019, our head office will be relocating from Islington to a new office space in Stratford, close to the Olympic Park.