Storm Therapeutics is a small drug discovery company working in the emerging field of RNA epigenetics. We are now looking to recruit an RNA biologist in our labs at the Babraham Research Campus near Cambridge. This will be a tremendous opportunity for an experienced molecular biologist to bring their expertise in working with RNA to a fast-paced biotech company and contribute to our understanding of the role of RNA modifications in cancer. Storm maintains close links with their academic founders, and the role would be at the interface of academia and industry.
The role will involve developing and establishing approaches to analyse the functional consequences of post-transcriptional modifications on different RNA species, including mRNA and non-coding RNAs. This work will complement our existing expertise in RNA modification and molecular pathway analyses and will be central to strengthening our core RNA analysis platform. Responsibilities in this position will include pioneering and establishing methods to monitor the fate of RNA molecules upon genetic or pharmacological inhibition of RNA-modifying enzymes. The successful candidate will be working closely with different teams at Storm to support ongoing target validation and drug discovery projects by implementing new RNA analysis methods into existing workflows.
The position is available at the Scientist or Senior Scientist level depending on experience and qualifications.
STORM Therapeutics offers an industry-competitive salary and benefits package, exciting science, and a great place to work.
Qualifications and skills required
Essential qualifications and skills for this post:
• PhD in a relevant life science subject with a track record of working with RNA.
• Profound knowledge and expertise of RNA biology.
• Proficiency in RNA-related molecular biology methods, for example including: qRT-PCR, Northern blotting, RNA-Seq library preparation, isolation of RNA subfractions or specific RNA molecules, RNA-protein binding methods such as CLIP.
• Solid molecular biology and cell biology background, e.g. DNA purification and molecular cloning, western blotting, tissue culture.
• Ability to work independently and as part of a team.
• Candidates must be legally entitled to work in the UK.
Desirable additional skills:
• Previous experience in drug discovery or biotechnology.
• Experience in analysing RNA modifications by chemical derivatisation methods.
• Experience with cellular assays and cell-based methods such as immunofluorescence, RNA-FISH/RNAScope, metabolic labelling of RNA in cell culture.
• Hands-on experience with genetic manipulation of tissue culture cells by siRNA/shRNA or CRISPR.
• Knowledge of cancer biology.
• Bioinformatics skills.
About Storm Therapeutics
STORM Therapeutics is a University of Cambridge spin-out, translating the ground-breaking work of Professors Tony Kouzarides and Eric Miska in RNA epigenetics into the discovery of first-in-class drugs in oncology and other diseases. It is the leading company tackling cancer through the modulation of RNA modifying enzymes, including RNA methyltransferases, exemplified by the development of a first-in-class METTL3 inhibitor (Yankova et al., Nature 2021). STORM has developed a unique platform to pioneer drug development in this new field and established a pipeline of projects, aiming to take them to the clinic.
STORM is backed by blue chip investors Cambridge Innovation Capital, Merck Ventures, Pfizer Ventures, Taiho Ventures LLC, IP Group and Seroba Life Sciences who share the founders’ ambitions to build a world-leading company in the field. The company occupies modern, well-equipped laboratories on the Babraham Research Campus near Cambridge.
Please apply to: firstname.lastname@example.org with a CV and covering letter, indicating where you heard about the job advert.