Scientist/Senior Scientist, Discovery Screening (Functional Genomics)
at Bit Bio
bit.bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At bit.bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics.
As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.
Location: Babraham Research Park, Cambridge
Type: Full time, permanent /
Salary: Competitive / Hours: 40 p/w
Lab based position
Your role in our team:
We are looking for a Scientist/Senior Scientist with experience in molecular biology and mammalian tissue culture to join our Discovery Screening Team.
You will be part of a dynamic team that develop, optimize, and perform genetic screening with the aim of generating terminally differentiated target cell types from iPSCs.
Reporting to the Discovery Team Lead, the post holder will work with a team of scientists as a focal point within the wider R&D department. You will support the target cell type Discovery programmes by providing high quality deliverables and expertise as well as develop and implement existing technology or novel scientific advancements in cellular programming, as pertains to the Discovery Screening Team and company-wide goals and objectives. The post holder will be expected to manage a small team of Research Assistants and as such will be required to lead in the continuous training and development of staff.
The Functional Genomics Department plays a pivotal role in bit.bio’s mission to develop cell types for research and clinical use. The Department consists of 6 individual teams and 30 core scientists that work closely together and lean on individual internal team expertise to further develop our core platforms and clinical assets. Led by experts in their fields, these include the following teams: Discovery, Next Generation Sequencing, Automation, Technical Development, Cellular, Engineering and Synthetic Biology.
Your key responsibilities will include:
To be accountable and responsible for executing the delivery of genetic screens in iPSCs, including validation of putative screen hits.
Be responsible for optimising screening SOPs – iteratively developing our multifaceted platforms, ensuring that bit.bio remains a leader in functional genomics screening.
To work with bit.bio teams to develop and optimise protocols for the generation of iPSC reprogrammed cell types, and assist in the characterisation these cells phenotypically, functionally and molecularly
Engage and influence external collaborators (and suppliers). Be involved in initiating, developing and driving collaborations which are critical to the achievement of the team and company objectives and goals.
Oversee development and training activities; coach individuals to perform their roles effectively. Help to manage the performance of individuals who are failing to meet agreed standards.
Actively lead in developing and maintaining the core cultural aspects of the company.
Present finding at regular internal and external meetings. Deputise for the Team Lead as required.
Have a higher degree in Biological Sciences or equivalent experience
Are a good team player with an inquisitive mind and an ability to prioritise, organise and be responsible for your own workload and that of others.
You will be looking for a stimulating working environment where you can engage with different working groups to independently drive research projects and actively contribute to projects of others.
With essential experience in...
Strong experience of core Cell and Molecular Biology techniques
Extensive experience with mammalian cell culture and flow cytometry
Experience in handling iPSC and protocols for human IPS cell differentiation assays
Proven ability to communicate research/project outputs, through written or oral communication.
Excellent team working and networking skills, proven ability to influence on Scientific and non-scientific matters.
Ability to manage and prioritise own workload
Experience of high throughput genomics
Experienced in high throughput genetic screening approaches using mammalian cell lines
Experienced in constructing large libraries for screening (e.g. CRISPR, transgene, RNAi etc) - including QC, analysis and experimental requirements
Line management experience and track record of staff development
More reasons to join us:
bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.
We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.
Creativity and open minds are encouraged for everyone to contribute to the success of the company.
For information on how we will manage your data please see our Candidate Privacy Notice- https://www.bit.bio/candidate-privacy-notice