(Senior) Scientist – Discovery Pipeline

(Senior) Scientist – Discovery Pipeline




SRG is delighted to be partnering with an exciting start-up biotech company based in the Cambridge area. They are currently looking for a highly motivated Scientist to join the discovery team where you will be contributing to the development of novel TCR Therapeutics. This is a fantastic opportunity for someone looking to work in a dynamic environment and rapidly expand their knowledge and skillset.

Key Responsibilities:

• Intellectual leadership of the use of high-through-put cell sorting and single cell sequencing to efficiently recover human TCRs
• Designing and implementing protocols to specifically recover T cells
• Sorting/screening using a multi-parameter flow cytometer to sort and analyse desired cell populations
• Designing panels to further dissect T cell subsets
• Development and application of LIBRA-Seq/Beam-Seq (10X Genomics) for TCR discovery
• Contributing to the development of microfluidics based single cell technology for TCR discovery
• Development, QC and use of in-house manufactured probes by working with protein & technology development teams
• Library construction for PCR/NGS processes
• Establishment, review, and updates of SOPs

Ideal Candidate:

• A Ph.D. (or equivalent experience) in Immunology/Cell Biology/Molecular Biology or similar with a strong flow core/immune-assays background
• Several years of postdoctoral experience in an academic or industry setting
• Extensive experience in designing and testing multi-parameter panels for analysis and sorting
• Extensive experience with flow analysis software (e.g. FACSDiva, FlowJo)
• Significant practical laboratory experience working with primary and immortalised mammalian cell lines
• Experience in design and setting up Microfluidics based assays
• Experience in single cell technology and library preparation (desirable)
• Demonstrated skills in trouble shooting and technology development

Application Instructions: 

If you are interested in discussing the role further, then please reach out to me at paige.keenan@srgtalent.com / 02039379660

Application Closing Date: 
31 March 2023