Senior Scientist – Native Mass Spectrometry

OMass Therapeutics is inviting applications for the position of Senior Scientist to work within the Biology Mass Spectrometry team. The company offers a thriving and creative environment for a well-suited candidate to become an integral part of our future vision.

The successful candidate will be an experienced scientist with a good understanding of mass spectrometry, particularly in native MS applications to understand protein interactions. You will be responsible for developing MS based methods which (i) provide a greater understanding of membrane proteins of interest and (ii) contribute to the development of a bespoke discovery platform for challenging drug targets. Experience of molecular biology, protein expression/purification is advantageous. As part of the platform development team, the ability to problem-solve and develop innovative solutions within projects is a key attribute required for the role. The role is based in our Oxford site.

Essential Experience and Skills
• A PhD or equivalent in biological/protein mass spectrometry with demonstratable research experience in native mass spectrometry
• Demonstrate the ability to lead research projects
• Experience with handling purified proteins
• Excellent organisational skills and communication skills, both written and verbal

Preferred Experience and Skills
• Experience in proteomics method development
• Native mass spectrometry experience on orbitrap platforms
• Experience in handling purified membrane proteins
• Experience with eukaryotic protein expression using a variety of hosts including mammalian and insect cells
• Experience with variety of protein purification methods
Role Responsibilities
• Develop mass spectrometry-based methods and protocols for drug discovery applications
• Apply native mass spectrometry to proteins (including membrane proteins) of interest to provide greater understanding of their structure and/or function.
• Prepare and apply OMass’ compound libraries to MS-based screens
• Work closely with scientists within the team to develop solutions and exploratory ideas which contribute to the company’s vision
• Liaise closely with other departments and scientists of different disciplines to deliver projects
• Create ideas and solutions which allow the company to deliver key milestones
• Maintain detailed laboratory records and, when required, contribute to the preparation of patents and publications
• Remain up to date with the state-of-the-art of the field
• Communicate research and data to broader project teams and provide expert opinion on its interpretation.