Synthetic Chemist

Headquartered in York, we are a biotechnology company developing an exciting market for the supply of custom nucleic acid aptamers for use across a range of disciplines. We have state-of-the-art high-throughput robotics to enable rapid identification, development, and characterisation of aptamers.

The Synthetic Chemist will play a key role in our aptamer production workflow, they will work closely with both the production and R&D team to fulfil customer and research related goals. The successful candidate will be responsible for the design, synthesis, and analysis of DNA and RNA aptamers and will operate automated synthesisers. Full training will be provided.

Role and Responsibilities

• Design and perform solid-phase synthesis, purification, and analysis of novel aptamers with chemical modifications.
• Operate and maintain automated synthesis platforms, HPLCs and other scientific equipment.
• Perform method/process development for improved aptamer synthesis and purification processes.
• Provide synthesis support to ongoing research & development activities
• Author standard operating procedures and maintain well documented electronic/laboratory notebooks.

“The above list of job duties is not exclusive or exhaustive and the post holder will be required to undertake such tasks as may reasonably be expected within the scope and grading of the post.”

Required Skills and Expertise
• A degree or PhD in medicinal or synthetic organic chemistry.
• A strong record of synthesis, purification, and analysis of bio-active molecules is required.
• Proven ability to conduct self-directed research, troubleshooting and of working effectively in a dynamic environment within a diverse team.
• Experience of following SOPs/protocols within a Class 2 laboratory

Preferred Skills

• Expertise in nucleoside chemistry and chemical modifications of oligonucleotides.
• Experience in using automated synthesisers.
• Knowledge of aptamer therapeutics, aptamer generation, or aptamer discovery.
• Background experience in development, production, and purification of novel phosphoramidites for integration into aptamer synthesis workflows