Creative Biolabs has developed a multi-layered model system and offers the global community preclinical research tools that better mimic human physiological characteristics.

In vivo disease models bridge the gap between the fundamental science and the drug candidate validation. The rodent models have long been used to understand the cancer mechanisms, immune system responses, and drug action pathways, and model relevance is being enhanced by genetic engineering and humanization technologies.

"Successful drug discovery increasingly depends on the biological relevance of the models," said the director of animal model research at Creative Biolabs. "We strive to make every experimental measurement reflect the human response as closely as possible."

Rodent Models: Preclinical Research's Benchmark
Rodent models continue to shape research in preclinical oncology, immunology, and neurodegenerative disease. Their small size, rapid reproduction, and ease of genetic manipulation have accelerated the development of rodent model systems. The customized rodent models developed by Creative Biolabs build on years of experimentation and now include syngeneic and xenograft models and humanized models for the evaluation of ADCs, CAR-Ts, and cancer vaccines.

These models allow researchers to track tumor growth, metastasis, and immune responses in vivo, providing quantifiable data to guide new drug screening.

Genetically Engineered Models: Recapitulating Disease Biology
Gene editing technologies notably improve the accuracy of models created to understand the molecular mechanisms of a given disease. Creative Biolabs engages in various methods of genetic engineering to develop tailored research animal models that include:
* Knockout (KO) models
* Knockin (KI) models
* Knockdown (KD) models

Using CRISPR, TALEN, DNA microinjection, and transposon-mediated approaches, Creative Biolabs can rapidly implement targeted gene mutations in fertilized eggs or embryonic stem cells, accurately recapitulating critical disease-related genetic features.

Humanized Mouse Models: Bridging Human Biology
Although mouse models are invaluable for mechanism studies, their immune systems differ significantly from humans, making it difficult to evaluate drugs targeting human-specific pathways. Creative Biolabs has developed multiple humanized mouse models, reconstructing functional human immune systems through transplantation of human hematopoietic stem cells or tissues.

These models include humanized PBL SCID mice, humanized SRC SCID mice, humanized BLT mice, and immune checkpoint knockin models. They are widely used in tumor immunotherapy, infectious disease research, graft-versus-host disease, and immune regulation studies.

"Valuable preclinical research is about seeing 'human-like responses' in animal models. Humanized models allow us to accurately predict immune responses that will reliably support immunotherapy optimization."