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At Cancer Research UK, we exist to beat cancer. 

We have an exciting opportunity at Cancer Research Horizons for a skilled Principal scientist to join the Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre based in Cambridge. 

The Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre (FGC), launched in 2019, is a state-of-the-art facility dedicated to unlocking the full potential of functional genomics for novel cancer therapeutics. As a centre of excellence, the FGC specialises in advanced functional genomics screening technologies, sophisticated cancer models, and computational approaches for 'big data' analysis.  You will be joining a dynamic and diverse team under the leadership of David Walter. 

This role offers the unique opportunity to be part of an exciting team, operating at the forefront of research and technology development, gaining experience across the breadth of CRISPR technologies whilst it is being applied to clinically actionable programs.  Working in a diverse, dynamic, and cutting-edge scientific environment, this laboratory-based role will give you the opportunity to apply your molecular and cell biology and drug discovery expertise to build new capabilities and support our functional genomic screening efforts. 

About Cancer Research Horizons   

As the world’s biggest medical research charity, we’ve helped bring fourteen new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. 

Cancer Research Horizons (CRH) is CRUK’s internal translation engine. CRUK’s established drug discovery teams operate under one organisation and leadership team. Our unique combination of cancer biology expertise and access to CRUK’s world-class academic network, coupled with cutting edge technology platforms and clinical expertise enables us to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.  

Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, Cancer Research Horizons employs ~180 staff from both industrial and academic backgrounds 

Application Closing Date:
9 August 2026
Salary:
£57,000- £64,400 per annum (dependent on experience) plus benefits