Never losing sight of our purpose

At Mestag we truly believe in our values and live by them every day.  We’re ambitious about our science and its potential to deliver meaningful therapeutics to the patients that need them most. We believe in a culture of diversity, equality and investing in people to ensure our talented and passionate team members can fulfil their full potential.

We are now transitioning our lead programme into clinic - There has never been a better time to join #TeamMestag

Scope of role

The Program Lead will be responsible for the leadership of our M300 clinical program. This is a senior opening but also requires a hands-on approach , bridging clinical operations, CMC, translational and development program management, ensuring seamless execution across functions and external partners in readiness for future Phase II/III development.

Key Responsibilities
 

• Partnering with the program’s project manager, with internal and external experts in research, Translational Science & bioanalytical, CMC, Clinical, Clinical Operations, Biostatistics, PK and Regulatory, to ensure the timely execution of the program strategy and operational plans
• Provide alignment of internal teams, CROs, and external stakeholders.
• Partner with the CMO & regulatory teams to lead clinical protocol development and amendments including first-in-human, safety, PK/PD, DLT, and biomarker-driven expansion plans.
• Collaborating with the program’s project manager to track and own program timelines, budgets, and deliverables.
• Develop and maintain risk mitigation strategies
• Provide transparent program reporting to leadership and governance bodies, externally as required.
• Serve as subject matter expert for the investigational therapeutic, integrating preclinical, biomarker, and PK/PD data into patient safety and efficacy assessments.
• Provide input to regulatory and clinical documents, and key publications.
• Together with the CMO and clinical operations team, engage with investigators, clinical sites, and key opinion leaders in immuno-oncology to build relationships and to enable smooth progress of the clinical trial and planning for future development
• Drive and support interactions with regulatory agencies and development partners.

Experience

• Advanced scientific OR medical degree (MD, PhD, PharmD preferred) in oncology, immunology, or related field.
• Extensive experience in oncology drug development, with previous experience  of leading early-phase (Phase 1/1b) programs.
• Demonstrated leadership in immune-oncology projects (e.g., checkpoint inhibitors, bispecifics).
• Proven ability to manage cross functional teams, budgets, and operational timelines in a biotech environment.
• Comprehensive understanding of therapeutic antibody safety pharmacology, PK/PD, biomarkers, and CMC.
• Strong written and oral communication skills; prior experience with Health Authority interactions desirable.

Personal Attributes

• Collaborative, informal and positive leadership style, ability to successfully navigate multiple viewpoints to align a multi-expert team
• Entrepreneurial mindset and comfort working within a small, fast-moving team.
• Strategic thinker with hands-on execution ability.
• Collaborative and scientifically curious, able to bridge biology and clinical development.
• Committed to advancing transformative treatments for patients with cancer

In return we can offer you

We work flexibly with a strong team spirit and offer a highly competitive total rewards package including competitive salaries, pension contributions, private medical insurance, income protection and more.

We have access to a range of onsite facilities including a gym, canteen, golf course and free onsite parking.

As a team we achieve great things each day, and we take the time to celebrate successes, share and learn. We value the relationships of our close-knit team and strive to make meaningful connections in our community. We frequently hold Town Halls and team lunches, and have an active social committee, organizing regular events and ‘giving back’ activities supporting charities close to our hearts.

Feel free to have an informal discussion with us for any questions you may have, we are happy to talk to you.  However please send your CV in the first instance.

About Mestag Therapeutics

Mestag harnesses new insights into fibroblast-immune interactions to develop impactful treatments for patients. We are progressing a pipeline of sophisticated first-in-class antibodies designed to improve the lives of patients with cancer and inflammatory disease.  Together with our collaboration partner MSD, we are also identifying novel targets for future therapies.

We are based in spacious and modern laboratory and office facilities at Chesterford Research Park near Cambridge, UK – right in the very heart of the UK life science sector. Our facilities are kitted out with state-of-the-art instruments to enable our dedicated researchers to deliver incredible science.

Mestag is backed by committed leading global investors, has world-class founders and a highly experienced leadership team.

Our founding investigators comprise global experts in inflammatory disease, cancer, computational biology and fibroblast biology from the University of Oxford, Brigham & Women’s Hospital, Harvard Medical School and Cold Spring Harbor Laboratory. We are supported by leading life science investors SV Health Investors, Johnson & Johnson Innovation – JJDC, Inc., Forbion, GV (formerly Google Ventures) and Northpond Ventures.

Mestag is headquartered in Cambridge, UK, and in 2021 was recognized on the Fierce 15 list of innovative biotechnology companies.

For further information please visit our website www.mestagtherapeutics.com