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Tony Jones
CEO, 
One Nucleus

Springing Forward in 2026  
As the temperatures rise, flowers begin to bloom, and the deal flow reports keep coming; it feels like biotech may have a spring in its step. April storms and showers to dampen the mood are circling for many still; however, it is far from a universal bed of roses. 

Thirty-six investment rounds were announced during Q1/2026, amounting to nearly £0.5Bn venture investment across the London and Cambridge areas alone in the sector. Notable rounds were secured by Mestag Therapeutics, Nuclera, Tenpoint Therapeutics, Bit Bio and Immutrin demonstrating investor appetite.


That is not reliably translating to filling lab facilities and retaining R&D staff in the UK, however, with some undesired news from primary and R&D services companies. This dual aspect activity continues to be reflected in One Nucleus’ support of our members.

Celebrating Success 
The evening of 19 March saw the One Nucleus family celebrate its successes at the Annual Awards Dinner in London. Ten worthy winners recognised by their peers, representing excellence across the ecosystem from R&D to professional services and facilities. Preceding this, One Nucleus was delighted to be involved in showcasing the Cambridge x London cluster through the 20+ company pitches organised by Prashant Shah and others at RESI JPM and to have arrived at the winner selection for the One Nucleus Boston Bootcamp 2026, again taking excellent examples of member companies to MA for the week.

Continuing Support
Enabling members to make the most of opportunities is behind our Upskilling Seminars series, launched with the ‘Business Lead Generation from Events’ session earlier this month. Not just through One Nucleus efforts, but through its ongoing commitment to collaborating with leading global bio-partnering and investment conference organisers such as EBD Group, Life Science Nation and LSX, it ensures we seek to help members prepare for, raise their profile at and maximise return from these cornerstone events.

Readers are encouraged to check out upcoming discounts and opportunities that fit their needs, including at US-based events such as the BIONJ BioPartnering Conference, BIO International Convention and 8th T-Cell Engager Therapeutics Summit.
 
Engaging When it is Not Going Well 
Equally, we remain active in supporting those negatively impacted by the current life science landscape. Through our support for those caught up in the high levels of redundancy we will have an open webinar on 9 April to gather views on what the call-to-action should look like that we’d like the government and those influencing policy to bring urgency to.

Stay Up To Date
I am delighted that within this quarterly e-newsletter there are linked articles from One Nucleus colleagues Philippa Clark, Monalisa Breazu and Alicia Gailliez expanding on my summary above, along with the latest spin-out investment report from Penningtons Manches Cooper, a longstanding member of the One Nucleus Partner Programme. 

Remain informed of all One Nucleus updates, disseminate your company’s news, or track the announcements from other members, and make full use of our website, LinkedIn, or X pages. The news stream contains numerous updates from our community. Enjoy the read!

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Boston Bootcamp 2026: Meet the Winners, Insights So Far and What’s Next
The winners of the Boston Bootcamp 2026 have been announced! Congratulations to ExpressionEdits, Monument Therapeutics, Profionics, and Stick Therapeutics. What happens next? Read the update by Alicia Gailliez, Business Development Manager, One Nucleus here

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Reflections from Belgium: The Value of Cross Border Collaboration
One Nucleus’ recently joined VIB and Biovia the Flanders-UK Partnering in Ghent, Belgium. Read the article by Philippa Clark, Director of Business Development, One Nucleus on how energising it can be to step into another ecosystem.  

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ON Helix 2026: What Debates are Shaping the Future of Biotech? 
Breakthroughs are accelerating across therapeutics, data platforms, regulatory systems and business models. Yet challenges remain in how we develop and scale innovation within an increasingly complex landscape. Read the programme highlights covering these challenges at ON Helix 2026 in July by Alicia Gailliez, Business Development Manager, One Nucleus. 

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What if Women’s Biology is One of Science’s Biggest Missed Opportunities?
Has women’s health been underserved or does women’s biology itself represent one of the most underexplored opportunities in science? Philippa Clark, Director of Business Development, One Nucleus explores recent insights from the ecosystem.

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Lead Generation Isn’t About the Hard Sell; It’s About Solving the Right Problems
A recent lead generation seminar highlighted that successful lead generation is rarely about saying more. It is usually about saying the right thing, to the right people, at the right time, and doing it in a way that feels relevant, useful and human. Read key take-aways from the seminar by Monalisa Breazu, Learning & Development Administrator. 

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Penningtons Manches Cooper Partners With Beauhurst to Sponsor New Report on Investment Into UK Spinouts 
Penningtons Manches Cooper has partnered with Beauhurst, a leading private company data platform, to launch its latest report on the UK spinouts landscape. Read the report

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