We are growing our scientific team at ExpressionEdits and are offering an opportunity to join us in a full-time role as a Senior Laboratory Technician based at our laboratories in the Babraham Research Campus near Cambridge.

About ExpressionEdits:

At ExpressionEdits, we are revolutionizing biotechnology to create therapeutics that nobody else can. We have gone back to the basic building block of the field, the transgene, which has remained essentially stagnant since the 1970s, and re-invented its design based on our proprietary method of intronization.

With this technology, we can turn the artificial transgenes of the past into sequences that incorporate both coding and non-coding DNA to express more effectively, while also looking more like a cell’s natural genes. We believe this approach, guided by our artificial intelligence “Engine” for genetic design, will allow us to bring forth the full potential of genetic production.

We are a growing startup company within Cambridge’s synthetic biology community which you can join as an early member of our diverse team that spans biology, engineering, data science, and operations. With your help, we can bring our vision of ‘building biology like nature’ to life.

Position Overview:

We are seeking a motivated Senior Laboratory Technician to join the ExpressionEdits wet lab team.

Reporting to the Laboratory & Facilities Senior Manager and collaborating closely with the wet lab team, the Senior Laboratory Technician will play a key hands-on role in advancing the development and validation of the Genetic Syntax Engine by supporting various internal research initiatives.

This position involves executing and reporting on planned experimental work, utilizing a diverse array of molecular and cell biology techniques, and operating specialized laboratory equipment. The Senior Laboratory Technician will work cross-functionally with the wet lab and lab operations teams to drive research efficiency. A crucial aspect of this role is ensuring the seamless upkeeping of laboratory functions, contributing to a high-functioning research environment.

Responsibilities:

Cell culture:
• Perform aseptic technique in cell culture.
• Maintain and manage both suspension and adherent cell cultures, including cell expansion, troubleshooting, and implementing new protocols for the wet lab scientific team.
• Conduct transient transfections for multiple projects.
• Establish and develop integrated cell lines for research applications.
• Plan and execute large-scale cellular experiments.
• Perform routine mycoplasma testing to ensure cell culture integrity.

Molecular biology techniques:
• Conduct nucleic acid extractions including mini, midi and maxi scales - DNA and RNA.
• Perform general cloning techniques including, PCR, Gibson assembly and gel electrophoresis.
• Run large-scale experiments as well as high-throughput miniaturized assays.

Laboratory Operations & maintenance:
• Prepare laboratory solutions including buffers, media and reagent aliquots.
• Manage autoclaving, glass washing and waste disposal.
• Conduct routine equipment cleaning, troubleshooting, and maintenance checks.
• Manage lab supplies including requisitioning, inventory tracking and stock control.

Qualifications and Experience:

Essential:
• BSc in a biological science or equivalent experience.
• Strong practical hands-on experience in cell culture in an academic or industry setting.

Desirable:
• Industrial / Biotechnology work experience.
• Experience in molecular biology techniques such as PCR, nucleic acid extraction, cloning and protein-based assays including ELISA and SDS-PAGE/Western Blotting.
• Experience in using LIMS or other electronic systems for recording experimental results to high standards of detail.

Skills & Attributes:

• Strong scientific integrity and attention to detail.
• Demonstrated ability to interpret data and troubleshoot protocols.
• Excellent organisational skills.
• Excellent verbal and written communication skills, with the ability to communicate effectively with other team members.
• Highly organized, proactive, adaptable with the ability to multitask effectively in a fast-paced laboratory environment.
• Strong communication and teamwork skills, fostering collaboration across teams.
• Flexible and solutions-orientated approach to work; ability to support colleagues and prioritize tasks based on shifting company priorities.
• Desire to continuous learning and professional growth; eager to develop new skills in alignment with the company’s scientific advancements.