At Broken String Biosciences, we are driving innovation in genome editing technologies to enable safer, more effective cell and gene therapies. Our mission is to advance the next generation of precise, safe, and efficient therapies through our cutting-edge technology platforms.

Our flagship technology, INDUCE-seq™, offers rapid and accurate DNA break mapping, providing critical insights into how genome editors interact with DNA. This data-driven approach helps unlock new editing targets and supports the development of life-saving therapies that are safer by design.

With a vision to transform healthcare, we are committed to delivering solutions that make cell and gene therapies more accessible, efficient, and safe for patients worldwide.

About the Role

The Senior Manufacturing Manager will be responsible for developing and managing the contract manufacturing process for Broken String, working primarily with a US-based manufacturing partner. This role involves collaborating across multiple internal functions including Product Development, Operations, Commercial, and Finance, ensuring the effective transfer of design to manufacturing and supporting product launches.

The role will focus on both short-term objectives, such as the initial NPI and early access product launch, and long-term goals related to the full-scale launch and supporting processes. The Senior Manufacturing Manager will need to balance day-to-day operational responsibilities with the broader strategic development of manufacturing processes.

Role Responsibilities

• Manage the relationship with the CMO, including negotiating terms, monitoring performance, and troubleshooting operational issues.
• Oversee contract negotiations, SLAs, and ensure alignment with business and product needs.
• Enable successful NPI and design transfer processes.
• Ensure the contract manufacturer can meet current and future production demands, with plans for scalability.
• Work with internal teams to use forecast information to plan for capacity changes based on product launches and growth.
• Identify and manage risks related to external manufacturing, including supply chain disruptions and regulatory compliance.
• Support internal and external audits, ensuring corrective actions are addressed.
• Manage manufacturing budgets, working with the finance team to optimise costs without sacrificing quality or timelines.
• Develop and track KPIs for the CMO, focusing on quality, delivery, and cost metrics.
• Drive continuous improvement initiatives with the CMO to improve efficiency and reduce waste.
• Collaborate with QA on process validation at CMO.
• Collaborate with supply chain teams to ensure materials, components, and products are delivered on time.
• Oversee inventory levels in coordination with the contract manufacturer’s production schedule.
• Act as the main point of contact for resolving production, delivery, or quality issues with the contract manufacturer.

Top 5 Must Haves:

1. Design Transfer and/or NPI Experience
2. Experience of change management in manufacturing
3. Influencing without authority
4. Experience of working under a Quality Management System
5. Willingness and ability for occasional travel to US based manufacturer

Other key Experiences, Skills or Qualifications

• Bachelor's degree in Biological Sciences, Engineering, or a related field.
• At least 5 years of industry experience, with a focus on managing contract manufacturing or in-house manufacturing in the medical device, pharmaceutical, or biotechnology sectors.
• Experience with design transfer and new product introduction (NPI).
• Demonstrated ability in change management within manufacturing environments.
• Experience working under a Quality Management System (QMS).
• Proven track record of cross-functional collaboration, particularly in product launch and forecasting processes.
• Experience developing and monitoring supplier KPIs.
• Highly organised with strong communication and collaboration skills.
• Willingness and ability to travel to the US as needed.

Bonus Experiences

• Six Sigma or other process improvement certifications is preferrable.
• Experience with ERP systems or ERP implementation will help.

Behaviours

• Effectively negotiate and guide external partners and internal teams, even without direct control, to achieve desired outcomes.
• Quickly assess and resolve production, supply chain, and operational issues to keep manufacturing on track.
• Work seamlessly with cross-functional teams and external partners to ensure smooth design transfers and product launches.
• Build and maintain strong relationships across the industry to leverage external expertise, resources, and best practices for continuous improvement.
• Adjust to evolving challenges and manage change effectively in manufacturing processes and product launches.

Compensation & Benefits

Salary: £70,000 to £75,000

Discretionary Bonus

Company Share Options

Pension Contribution Match

Private Medical Insurance

Life Assurance

25 Days Annual Leave

Additional paid leave between Christmas and New Year

Company Values

• We are Passionate in Delivering Disruptive Solutions
• We Engage, Collaborate and Actively Support
• We Make our Customers our Partners
• We Ensure Every Voice is Heard

Interview Process

We aim to make the interview process smooth and transparent, ensuring you have a clear understanding of what to expect at each stage.

Step 1: Application Review - After you submit your application, the HRBP and Hiring Manager will review your qualifications.

Step 2: Initial Screening Call - A short Teams call of no more than 45 minutes with our HRBP or Hiring Manager to discuss your background, career goals, motivations and initial alignment with the role and company culture.

Step 3: 1st Stage Interview - If you have had an initial screening call with the HRBP, you will then be asked to meet with the hiring manager. This is an opportunity to dive deeper into your experience, learn more about the role, and see how you might collaborate with the team. This might be in person or over Teams and will last between 45-60 minutes.

Step 4: Panel Interview with Technical/Skills Assessment - Depending on the role, you may be asked to complete a short assessment or task that reflects the kind of work you'll be doing. This helps us understand your approach and problem-solving skills. This will generally be presented to a panel of key stakeholders and takes 60-90 minutes.

Step 5: Final Interview - For key roles, the final stage will involve a meeting with our CEO and Founder. This is an opportunity to discuss how your skills align with the company’s vision and strategic goals. You’ll also have a chance to ask any final questions about the role and the direction of the business.

Step 6: Offer Stage - If we mutually agree that the role is the right fit, we’ll extend a formal offer.

This is a guidance and sometimes we need to deviate from the above to accommodate for leave and other business activities.

At each stage of the recruitment process, we will aim to provide detailed feedback regardless of the outcome.

Diversity, Equity, & Inclusion Commitment

At Broken String, we celebrate diversity in all its forms, and strive to create a workplace where every individual’s unique strengths are recognised and valued. We are committed to fostering an inclusive and supportive environment where everyone—regardless of background, abilities, or ways of thinking—can thrive.

If you meet the top five criteria for this role, we strongly encourage you to apply. We believe that diverse perspectives bring innovation and creativity to our team. Even if you don’t meet every single requirement, your unique skills and experiences could be exactly what we’re looking for.

Join us in building a diverse, equitable, and inclusive future at Broken String, where everyone has the opportunity to succeed.