TBI is a leading cause of death and disability, costs the UK economy over £10 billion, and the global economy over $500 billion, annually. Outcomes from TBI are poor – even with “mild” TBI, 30% of patients show incomplete recovery at six months post-injury. The scope for improvement (and potential market opportunity) is substantial. While many past trials have failed, the substantial new knowledge provides a timely opportunity to address this issue. In response, UK research funders have invested in two complementary initiatives that aim to reduce development risk for companies, accelerate clinical evaluation, and generate the evidence needed for investment, regulatory progression and NHS adoption:

The UK-TBI REpository and data PORTal Enabling discoveRy (TBI-REPORTER; https://tbi-reporter.uk/) is a multi-funder (UKRI, NIHR, MoD, ARUK) platform supporting clinical research and early-stage therapeutic development in TBI. It brings together a Data Hub, National Biomarker Resource, Experimental Medicine Network and Patient and Public Involvement and Engagement (PPIE) programme to enable research-ready studies, biomarker-driven trials and collaborations between academia and industry.

The NIHR HealthTech Research Centre in Brain Injury (NIHR HRC; https://hrc-braininjury.nihr.ac.uk/) supports the development, evaluation and implementation of innovative technologies across the brain injury pathway, from prevention and acute care to rehabilitation and lifelong support. Working with industry, clinicians and researchers, the Centre helps translate promising technologies into NHS practice.

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