In this webinar, Dr Emma Jones explores how human iPSC-derived CNS models are used to study neuroinflammation across 2D and 3D systems, highlighting microglia-driven responses, tri-culture integration, and functional readouts in bioprinted 3D environments.

Key learning points

- How 2D human microglia models are characterised using functional readouts, imaging and single-cell analysis

- What changes when transitioning from 2D to 3D CNS models

- How microglia integrate into 3D tri-culture systems

- How functional assays (mitochondrial activity, cytokine release) can be applied in 3D model systems

- What 3D human CNS systems can reveal about neuroinflammatory response