Expanding Peptide Drug Discovery with Next-Generation Peptide DELs
Peptide therapeutics offer highly specific and versatile treatments for complex and previously undruggable targets. High-throughput peptide library screening has accelerated discovery. However, traditional platforms such as phage or mRNA display are inherently limited by biological translation processes. DNA-encoded library (DEL) technology provides an alternative, enabling incorporation of unnatural amino acids and diverse cyclization strategies, and producing peptides with improved stability and prolonged retention.